Department of Expanded Programme on Immunization, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, Jiangsu Province 210009, China.
Vaccine. 2011 Jan 29;29(5):1000-4. doi: 10.1016/j.vaccine.2010.11.081. Epub 2010 Dec 14.
A cross-sectional survey of measles seroprevalence in general population was conducted in Jiangsu province of China. Data were analyzed by employing commercial ELISA cut-offs and mixture models. The results suggest that the overall measles seroprevalence rate in Jiangsu province (88.7%, 95% confidence interval 87.7-89.6%) was lower than the level believed to be necessary for the elimination of measles. Mixture model could provide a more comprehensive understanding of these results by investigating the different levels of antibody response to vaccination or natural infection in the population, and suggest that the vaccine-induced antibody levels may wane with time. Additional actions should be conducted in the young adult cohorts aged 15-19 years in center region. SIAs for susceptible birth cohorts over the whole province are urgent.
在中国江苏省进行了一项麻疹血清流行率的横断面调查。数据采用商业 ELISA 截断值和混合模型进行分析。结果表明，江苏省的麻疹血清流行率总体为 88.7%（95%置信区间 87.7-89.6%），低于消除麻疹所需的水平。混合模型通过调查人群中对疫苗接种或自然感染的不同抗体反应水平，可以更全面地了解这些结果，并表明疫苗诱导的抗体水平可能随时间推移而下降。应在中部地区 15-19 岁的年轻成年人群中采取额外措施。全省易感出生队列的强化免疫活动迫在眉睫。
