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Responsibility of applicants for promoting objectivity in research for which public health service funding is sought and responsible prospective contractors. Final rule.寻求公共卫生服务资金的研究以及负责的潜在承包商的申请人在促进研究客观性方面的责任。最终规则。
Fed Regist. 2011 Aug 25;76(165):53256-93.
2
Recommendations for pathology peer review.病理学同行评审建议。
Toxicol Pathol. 2010 Dec;38(7):1118-27. doi: 10.1177/0192623310383991. Epub 2010 Oct 5.
3
Do pressures to publish increase scientists' bias? An empirical support from US States Data.发表压力会增加科学家的偏见吗?来自美国各州数据的实证支持。
PLoS One. 2010 Apr 21;5(4):e10271. doi: 10.1371/journal.pone.0010271.
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Publication bias in reports of animal stroke studies leads to major overstatement of efficacy.动物中风研究报告中的发表偏倚导致疗效的严重夸大。
PLoS Biol. 2010 Mar 30;8(3):e1000344. doi: 10.1371/journal.pbio.1000344.
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Good laboratory practices and safety assessments.良好实验室规范与安全评估。
Environ Health Perspect. 2009 Nov;117(11):A482-3; author reply A483-4. doi: 10.1289/ehp.0900884.
6
Chemical regulators have overreached.化学调节剂已超出其作用范围。
Nature. 2009 Aug 27;460(7259):1080-1. doi: 10.1038/4601080a.
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The French approach to deriving toxicity reference values: an example using reprotoxic effects.法国推导毒性参考值的方法:以生殖毒性效应为例。
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8
Regulatory demands on data quality for the environmental risk assessment of pharmaceuticals.药品环境风险评估的数据质量监管要求。
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"ToxRTool", a new tool to assess the reliability of toxicological data.“ToxRTool”,一种评估毒理学数据可靠性的新工具。
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Funding food science and nutrition research: financial conflicts and scientific integrity.资助食品科学与营养研究:财务冲突与科学诚信。
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提高化学品安全研究的可信度:关键评估标准的新共识。

Enhancing credibility of chemical safety studies: emerging consensus on key assessment criteria.

机构信息

Conrad Law and Policy Counsel, Washington, DC 20036, USA.

出版信息

Environ Health Perspect. 2011 Jun;119(6):757-64. doi: 10.1289/ehp.1002737. Epub 2010 Dec 15.

DOI:10.1289/ehp.1002737
PMID:21163723
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3114808/
Abstract

OBJECTIVES

We examined the extent to which consensus exists on the criteria that should be used for assessing the credibility of a scientific work, regardless of its funding source, and explored how these criteria might be implemented.

DATA SOURCES

Three publications, all presented at a session of the 2009 annual meeting of the Society for Risk Analysis, have proposed a range of criteria for evaluating the credibility of scientific studies. At least two other similar sets of criteria have recently been proposed elsewhere.

DATA EXTRACTION/SYNTHESIS: In this article we review these criteria, highlight the commonalities among them, and integrate them into a list of 10 criteria. We also discuss issues inherent in any attempt to implement the criteria systematically.

CONCLUSIONS

Recommendations by many scientists and policy experts converge on a finite list of criteria for assessing the credibility of a scientific study without regard to funding source. These criteria should be formalized through a consensus process or a governmental initiative that includes discussion and pilot application of a system for reproducibly implementing them. Formal establishment of such a system should enable the debate regarding chemical studies to move beyond funding issues and focus on scientific merit.

摘要

目的

我们研究了在何种程度上存在共识,即无论其资金来源如何,都应使用哪些标准来评估科学工作的可信度,并探讨了这些标准可能如何实施。

资料来源

三篇出版物均在 2009 年风险分析学会年会上的一次会议上提出,提出了一系列评估科学研究可信度的标准。最近在其他地方也提出了至少另外两套类似的标准。

资料提取/综合:在本文中,我们回顾了这些标准,突出了它们之间的共同点,并将其整合为 10 项标准列表。我们还讨论了系统实施这些标准所固有的问题。

结论

许多科学家和政策专家的建议都集中在评估科学研究可信度的有限标准上,而不考虑资金来源。这些标准应通过共识过程或政府倡议来正式确定,其中包括讨论和试行实施这些标准的系统。正式建立这样的系统应该使关于化学研究的辩论超越资金问题,而专注于科学价值。