淋巴细胞特异性蛋白酪氨酸激酶（LCK）抑制包括人类I型T细胞白血病病毒启动子在内的各种启动子的基因表达。
lck suppresses gene expression from various promoters including human T-cell leukemia virus type I promoter.
作者信息
Ohta M, Morita T, Shimotohno K
机构信息
Virology Division, National Cancer Center Research Institute, Tokyo.
出版信息
Jpn J Cancer Res. 1990 May;81(5):440-4. doi: 10.1111/j.1349-7006.1990.tb02588.x.
Abstract
The T-lymphocyte-specific tyrosine kinase gene, lck, is expressed in T-lymphocyte cell lines, except for several human T-cell leukemia virus type I(HTLV-I)-transformed T-lymphocyte cell lines, which produce HTLV-I. By introducing an lck-expression vector, we found that lck product suppresses gene expression from HTLV-I promoter in a transient assay. Moreover, various other promoters of cellular genes or viruses were found to have their transcriptional activity repressed by lck.
摘要
T淋巴细胞特异性酪氨酸激酶基因lck在T淋巴细胞系中表达，但不包括几种产生人类I型嗜T淋巴细胞病毒（HTLV-I）的HTLV-I转化的T淋巴细胞系。通过引入lck表达载体，我们发现在瞬时分析中lck产物可抑制HTLV-I启动子的基因表达。此外，还发现细胞基因或病毒的各种其他启动子的转录活性会被lck抑制。
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Proc Natl Acad Sci U S A. 1982 Nov;79(22):6777-81. doi: 10.1073/pnas.79.22.6777.
2
High-efficiency transformation of mammalian cells by plasmid DNA.质粒DNA对哺乳动物细胞的高效转化
Mol Cell Biol. 1987 Aug;7(8):2745-52. doi: 10.1128/mcb.7.8.2745-2752.1987.
3
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Mol Cell Biol. 1987 Dec;7(12):4407-13. doi: 10.1128/mcb.7.12.4407-4413.1987.
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Eur J Immunol. 1986 Dec;16(12):1643-6. doi: 10.1002/eji.1830161229.
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