Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario de Santiago, University of Santiago de Compostela, Santiago de Compostela, Spain.
Stroke. 2011 Jan;42(1 Suppl):S7-11. doi: 10.1161/STROKEAHA.110.596684. Epub 2010 Dec 16.
In the last 3 decades, and from a therapeutic point of view, the classical concept of ischemic penumbra based on hemodynamic and electrophysiological parameters has loosened up the rigidity of therapeutic windows in acute stroke management. Thirty years later, the ischemic penumbra is an evolved concept that presents more applications. Thus, the ischemic penumbra is a diagnostic target, allowing the extension of therapeutic windows; it is also a biochemical target, in which an intermittent bioenergetic compromise takes place, and it is a target for brain plasticity, neuroprotection, and neurorepair.
In this work, we review how the concept of ischemic penumbra has been evolving from its purely electrophysiological/ hemodynamic based definition to the wider metabolic-cellular-therapeutic concept that is managed today by neuroscientists.
在过去的 30 年中，从治疗的角度来看，基于血流动力学和电生理学参数的经典缺血半暗带概念放宽了急性卒中管理中治疗窗口的严格性。30 年后，缺血半暗带是一个演变的概念，具有更多的应用。因此，缺血半暗带既是一个诊断靶点，可以延长治疗窗口；也是一个生化靶点，其中发生间歇性的生物能量学损伤；也是脑可塑性、神经保护和神经修复的靶点。
在这项工作中，我们回顾了缺血半暗带概念是如何从纯粹基于电生理学/血流动力学的定义演变为今天神经科学家所管理的更广泛的代谢-细胞-治疗概念的。
