海洋生物碱查特林碱C的合成研究。
Studies towards the synthesis of the marine alkaloid chartelline C.
作者信息
Black Phillip J, Hecker Evan A, Magnus Philip
机构信息
Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712-1167, USA.
出版信息
Tetrahedron Lett. 2007 Sep 3;48(36):6364-6367. doi: 10.1016/j.tetlet.2007.07.040.
Abstract
The 2,6-dibromoindole 5 underwent regioselective Sonogashira coupling at the 2 position with simple acetylenic partners. While, the imidazole-acetylene 16 failed to couple to 5, the cyclic carbonate 19 succeeded to give 20, which was further elaborated into the indole-imidazole 23.
摘要
2,6 - 二溴吲哚5在2位与简单的炔类反应物发生区域选择性的Sonogashira偶联反应。然而，咪唑 - 乙炔16未能与5发生偶联反应，而环状碳酸酯19成功反应生成20，20进一步转化为吲哚 - 咪唑23。
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Construction of beta-haloenamides via direct copper-promoted coupling of lactams with 2-chloro and 2-bromo vinyliodides.通过内酰胺与2-氯和2-溴乙烯基碘的直接铜促进偶联构建β-卤代烯酰胺。
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J Org Chem. 2006 Apr 14;71(8):3159-66. doi: 10.1021/jo060084f.
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A remarkable ring contraction en route to the chartelline alkaloids.
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