Black Phillip J, Hecker Evan A, Magnus Philip
Department of Chemistry and Biochemistry, University of Texas at Austin, 1 University Station A5300, Austin, Texas 78712-1167, USA.
Tetrahedron Lett. 2007 Sep 3;48(36):6364-6367. doi: 10.1016/j.tetlet.2007.07.040.
The 2,6-dibromoindole 5 underwent regioselective Sonogashira coupling at the 2 position with simple acetylenic partners. While, the imidazole-acetylene 16 failed to couple to 5, the cyclic carbonate 19 succeeded to give 20, which was further elaborated into the indole-imidazole 23.
2,6 - 二溴吲哚5在2位与简单的炔类反应物发生区域选择性的Sonogashira偶联反应。然而，咪唑 - 乙炔16未能与5发生偶联反应，而环状碳酸酯19成功反应生成20，20进一步转化为吲哚 - 咪唑23。
