通过内酰胺与2-氯和2-溴乙烯基碘的直接铜促进偶联构建β-卤代烯酰胺。
Construction of beta-haloenamides via direct copper-promoted coupling of lactams with 2-chloro and 2-bromo vinyliodides.
作者信息
Sun Cuixiang, Camp Jason E, Weinreb Steven M
机构信息
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA.
出版信息
Org Lett. 2006 Apr 27;8(9):1779-81. doi: 10.1021/ol060093a.
PMID:16623549
Abstract
[reaction: see text] Cu(I)-catalyzed coupling of lactams with (E)-2-chlorovinyliodides or (E)-2-bromovinyliodides produces the corresponding beta-haloenamides in moderate to excellent yields.
摘要
[反应：见正文] 铜（I）催化内酰胺与（E）-2-氯乙烯基碘或（E）-2-溴乙烯基碘的偶联反应能以中等至优异的产率生成相应的β-卤代烯酰胺。
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