Godovalova O S
Laboratory of Nervous System Development, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia.
Bull Exp Biol Med. 2010 Oct;149(5):655-8. doi: 10.1007/s10517-010-1017-x.
We studied the distribution of glial fibrillary acidic protein (GFAP) and neuron-specific nuclear histone protein NeuN in sulci of the brain cortex during the pre- and postnatal ontogeny. The expression of GFAP during morphogenetic development of the sulci and gyri is cyclic. After functional reorientation of GFAP in human fetuses at weeks 28-30 it ceases to be a marker of morphogenetically active glia and becomes a marker of glial cells exclusively. Redistribution of NeuN expression in different layers of sulci during their formation was found: enhanced expression of NeuN in the cortical layer 6 of sulci and its reduced expression in the upper layers were noted, whereas outside the cortical sulci NeuN expression was similar in all layers. At weeks 24-25 of gestation, NeuN serves as a marker of ingrowth of secondary visual fibers from the dorsal thalamus.
我们研究了出生前和出生后个体发育过程中大脑皮质沟回中胶质纤维酸性蛋白（GFAP）和神经元特异性核组蛋白NeuN的分布情况。在脑沟回形态发生发育过程中，GFAP的表达呈周期性。在人类胎儿28 - 30周时GFAP功能重新定向后，它不再是形态发生活跃胶质细胞的标志物，而仅成为胶质细胞的标志物。发现在脑沟形成过程中NeuN在不同层的表达重新分布：脑沟皮质第6层中NeuN表达增强，而上层中其表达降低，而在皮质沟回以外，NeuN在所有层的表达相似。在妊娠24 - 25周时，NeuN作为来自背侧丘脑的次级视觉纤维长入的标志物。
