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单节段后路经椎间孔腰椎体间融合术联合局部植骨与髂嵴骨植骨的前瞻性随机研究:2 年随访结果

Single-level instrumented posterolateral fusion of the lumbar spine with a local bone graft versus an iliac crest bone graft: a prospective, randomized study with a 2-year follow-up.

机构信息

Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

出版信息

Eur Spine J. 2011 Apr;20(4):635-9. doi: 10.1007/s00586-010-1656-7. Epub 2010 Dec 17.

Abstract

The iliac crest bone grafting (ICBG) technique for lumbar posterolateral fusion surgery is widely used; however, donor site problems such as pain and sensory disturbance have been reported. Local bone is available for fusion surgery, but its reliability as a graft has not been fully reported. In the current study, we examined single-level instrumented posterolateral fusion with a local bone graft versus an ICBG in a prospective randomized study. Eighty-two patients diagnosed with L4 degenerated spondylolisthesis were divided into two groups at random. Forty-two patients underwent instrumented posterolateral fusion with a local bone graft (L4-L5 level), and 40 patients underwent instrumented posterolateral fusion with an ICBG (L4-L5 level). Rate and duration of bone union, visual analog scale (VAS) score, Japanese orthopedic association score (JOAS), Oswestry Disability Index (ODI), and complications were evaluated before and 2 years after therapy. VAS score, JOAS, and ODI were not significantly different between the two groups before and after surgery (P > 0.05). Rate and average duration of bone union were 90% and 8.5 months in the local bone graft group, and 85% and 7.7 months in the ICBG group, but without significant difference (P > 0.05). Prolonged surgical time and complications such as donor site pain (8 patients) and sensory disturbance (6 patients) were observed in the ICBG group. If single-level posterolateral fusion was performed, local bone graft technique has the same bone union rate compared with ICBG, requires less surgical time, and has fewer complications.

摘要

髂嵴骨移植(ICBG)技术广泛应用于腰椎后外侧融合术,但已有报道称该技术存在供区问题,如疼痛和感觉障碍。局部骨可用于融合手术,但作为移植物的可靠性尚未得到充分报道。在本研究中,我们在一项前瞻性随机研究中比较了单节段后路植骨融合与髂嵴骨移植。82 例 L4 退变性脊椎滑脱症患者被随机分为两组。42 例患者行后路植骨融合术(L4-L5 节段),40 例患者行髂嵴骨移植后路植骨融合术(L4-L5 节段)。评估两组患者治疗前后的植骨融合率和时间、视觉模拟评分(VAS)、日本矫形协会评分(JOAS)、Oswestry 残疾指数(ODI)以及并发症。两组患者术前和术后 VAS 评分、JOAS 和 ODI 无显著差异(P>0.05)。植骨融合率和平均融合时间在自体骨移植组分别为 90%和 8.5 个月,ICBG 组分别为 85%和 7.7 个月,但无显著差异(P>0.05)。ICBG 组手术时间延长,且存在供区疼痛(8 例)和感觉障碍(6 例)等并发症。对于单节段后路融合术,自体骨移植技术与 ICBG 具有相同的植骨融合率,手术时间更短,并发症更少。

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