Department of Pediatrics, Faculty of Medicine, Cairo University, Giza, Egypt.
Indian J Pediatr. 2011 Apr;78(4):418-22. doi: 10.1007/s12098-010-0308-6. Epub 2010 Dec 17.
To study extra- gastric manifestations of H. pylori infection among children in Egypt.
This case-control study in which thirty [corrected] H pylori positive children were compared to thirty [corrected] H pylori negative children was conducted. Full history taking, clinical examination, CBC, serum iron, serum ferritin in addition to H pylori antibody testing were performed.
Mean hemoglobin, MCV, MCH, serum iron and serum ferritin were all less in seropositive patients but these were statistically non significant. Iron deficiency (ID) was defined as serum ferritin less than 12 ng/ml; and Iron deficiency anemia (IDA) as hemoglobin less than 11 g/dL in addition to ID. Seropositive patients showed increased frequency of ID and IDA and this was statistically significant (0.003 & 0.000 respectively). There was no statistically significant difference as regards the platelet counts of the two groups or the presence of skin disorders or the gender.
There is increased incidence of ID and IDA among H pylori positive children. This needs to be confirmed by larger therapeutic randomized controlled trials. The hematological response to eradication therapy needs to be further studied.
研究埃及儿童中幽门螺杆菌感染的胃外表现。
这是一项病例对照研究，将 30 例幽门螺杆菌阳性儿童与 30 例幽门螺杆菌阴性儿童进行比较。进行了详细的病史采集、临床检查、CBC、血清铁、血清铁蛋白以及幽门螺杆菌抗体检测。
血清阳性患者的平均血红蛋白、MCV、MCH、血清铁和血清铁蛋白均较低，但无统计学意义。铁缺乏症（ID）定义为血清铁蛋白<12ng/ml；缺铁性贫血（IDA）定义为血红蛋白<11g/dL 并伴有 ID。血清阳性患者的 ID 和 IDA 发生率增加，具有统计学意义（分别为 0.003 和 0.000）。两组的血小板计数、皮肤疾病的存在或性别无统计学差异。
幽门螺杆菌阳性儿童中 ID 和 IDA 的发生率增加。这需要更大的治疗性随机对照试验来证实。根除治疗的血液学反应需要进一步研究。
