Department of Urology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Wuxi, China.
DNA Cell Biol. 2011 May;30(5):317-21. doi: 10.1089/dna.2010.1135. Epub 2010 Dec 17.
Oxidative DNA damage caused by reactive oxygen species plays an important role in cancer development. Human 8-oxoguanine DNA glycosylase (hOGG1) is involved in base excision repair of 8-oxoguanine from damaged DNA. We hypothesized that variants in the hOGG1 gene are associated with risk of renal cell carcinoma (RCC). In a hospital-based case-control study of 572 RCC patients and 575 cancer-free controls frequency matched by age and sex, we genotyped the functional polymorphism Ser326Cys (rs1052133) and assessed its associations with risk of RCC in a Chinese population. We found that individuals with the Cys allele were associated with an increased risk of RCC (odds ratio [OR] = 1.40, 95% confidence interval [CI] = 1.02-1.90), compared with those with the Ser/Ser genotype, particularly among subgroups of body mass index >24 kg/m(2) (OR = 1.75, 95% CI = 1.12-2.73) and non-smokers (OR = 1.60, 95% CI = 1.07-2.38). Further, the polymorphism was associated with risk of developing localized stage and well-differentiated RCC. Our results suggested that the polymorphism is involved in the etiology of RCC and thus may be a marker for genetic susceptibility to RCC.
活性氧自由基引起的氧化 DNA 损伤在癌症发展中起着重要作用。人类 8-氧鸟嘌呤 DNA 糖基化酶（hOGG1）参与受损 DNA 中 8-氧鸟嘌呤的碱基切除修复。我们假设 hOGG1 基因中的变异与肾细胞癌（RCC）的风险相关。在一项基于医院的 572 例 RCC 患者和 575 例癌症对照病例对照研究中，我们对功能性多态性 Ser326Cys（rs1052133）进行了基因分型，并评估了其在中国人群中与 RCC 风险的相关性。我们发现，与 Ser/Ser 基因型相比，携带 Cys 等位基因的个体患 RCC 的风险增加（比值比 [OR] = 1.40，95%置信区间 [CI] = 1.02-1.90），尤其是在体重指数（BMI）>24 kg/m(2)（OR = 1.75，95% CI = 1.12-2.73）和非吸烟者（OR = 1.60，95% CI = 1.07-2.38）亚组中。此外，该多态性与局限性和分化良好的 RCC 发病风险相关。我们的结果表明，该多态性参与了 RCC 的病因学，因此可能是 RCC 遗传易感性的标志物。
