rs1052133 基因型与台湾地区儿童急性淋巴细胞白血病风险的相关性。
rs1052133 Genotypes and Risk of Childhood Acute Lymphoblastic Leukemia in a Taiwanese Population.
机构信息
Department of Pediatrics, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan, R.O.C.
Taipei Cancer Center, Taipei Medical University, Taipei, Taiwan, R.O.C.
出版信息
In Vivo. 2019 Jul-Aug;33(4):1081-1086. doi: 10.21873/invivo.11576.
BACKGROUND/AIM: Cells suffer from oxidative DNA damage which leads to the accumulation of 8-oxoguanine (8-oxoG) adducts in our genome that can become carcinogenic. The human 8-oxoG DNA glycosylase 1 (hOGG1) plays a central role in repairing these 8-oxoGs via the base excision repair pathway. Mounting evidence has suggested that hOGG1 polymorphisms may affect the activity of hOGG1 and serve as genomic markers for the prediction of personal susceptibility to several cancers. To determine whether the commonly examined hOGG1 rs1052133 (Ser326Cys) polymorphism is associated with the risk of childhood acute lymphoblastic leukemia (ALL) among Taiwanese children, we genotyped the hOGG1 rs1052133 (Ser326Cys) in 266 cases and 266 controls.
RESULTS
The distributions of the GG, CG and CC genotypes at the hOGG1 rs1052133 were 49.2, 39.1 and 11.7% in the control group and 48.1, 36.1 and 15.8% in the case group (p=0.3656). The combined genotypes CG+CC were not associated with increased risk of childhood ALL (odds ratio [OR]=1.05, 95% confidence interval [CI]=0.74-1.47, p=0.7947).
CONCLUSION
The hOGG1 rs1052133 polymorphism is not associated with susceptibility to childhood ALL in the Taiwanese population.
背景/目的：细胞会遭受氧化 DNA 损伤，导致我们基因组中 8-氧鸟嘌呤（8-oxoG）加合物的积累，这些加合物可能具有致癌性。人类 8-氧鸟嘌呤 DNA 糖基化酶 1（hOGG1）在通过碱基切除修复途径修复这些 8-oxoG 方面发挥着核心作用。越来越多的证据表明，hOGG1 多态性可能影响 hOGG1 的活性，并作为预测个体易患多种癌症的基因组标志物。为了确定在台湾儿童中，常见检测的 hOGG1 rs1052133（Ser326Cys）多态性是否与儿童急性淋巴细胞白血病（ALL）的风险相关，我们对 266 例病例和 266 例对照进行了 hOGG1 rs1052133（Ser326Cys）基因分型。
结果
在对照组中，hOGG1 rs1052133 的 GG、CG 和 CC 基因型的分布分别为 49.2%、39.1%和 11.7%，而在病例组中则分别为 48.1%、36.1%和 15.8%（p=0.3656）。CG+CC 组合基因型与儿童 ALL 风险增加无关（比值比[OR]=1.05，95%置信区间[CI]=0.74-1.47，p=0.7947）。
结论
在台湾人群中，hOGG1 rs1052133 多态性与儿童 ALL 的易感性无关。
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