Significant Contribution of DNA Repair Genotypes to Renal Cell Carcinoma.

INTRODUCTION

DNA repair systems play essential roles in genomic stability and carcinogenesis. Therefore, genotypes at DNA repair loci may contribute to the determination of personal susceptibility to cancers. The contribution of () genotypes to renal cell carcinoma (RCC) is largely unknown. This study aimed to evaluate the contributions of rs1052133 genotypes to the RCC risk.

METHODS

We evaluated the contribution of rs1052133 (G/C) genotypes among 118 cases and 590 controls and analyzed the interactions of genotypes with smoking, alcohol drinking, hypertension, and diabetes status.

RESULTS

The rs1052133 CC genotype was significantly associated with a decreased RCC risk compared with that of the GG genotype (odds ratio [OR] = 0.25, 95% confidence interval [CI] = 0.09-0.72, = 0.0049). The frequency of the rs1052133 C allele was significantly low in the RCC group (22.5% vs 31.2%; OR = 0.64; 95% CI = 0.46-0.89, = 0.0074). Stratifying the analysis according to smoking, alcohol drinking, and diabetes status revealed no difference in the rs1052133 genotype distribution among these subgroups. A significant differential distribution of rs1052133 genotypes was observed among subjects with hypertension.

CONCLUSION

The CC genotype of rs1052133 may play a role in determining RCC susceptibility among Taiwanese people and may serve as a biomarker of RCC, particularly in patients with hypertension.