Department of Food Science and Center for Food Safety-IFSE, University of Arkansas, Fayetteville, AR 72704, USA.
Foodborne Pathog Dis. 2011 May;8(5):569-78. doi: 10.1089/fpd.2010.0718. Epub 2010 Dec 18.
Listeria monocytogenes is an opportunistic human pathogen that causes listeriosis, a disease that mainly affects the immunocompromised, the elderly, infants, and pregnant women. Listeriosis has become increasingly common in the last 25 years since the first foodborne outbreak was noted. Treatment for listeriosis currently consists primarily of supportive therapy in conjunction with the use of intravenous antibiotics. Antibiotics have been commercially available for over 60 years for treatment of a myriad of clinical diseases. Bacteria resistant to antibiotics have been developing over this same period. This review seeks to elucidate the extent of antibiotic resistance in L. monocytogenes, the possible transmission mechanisms, and contributing factors to distribution of antibiotic resistance among Listeria species, and possible control strategies.
单增李斯特菌是一种机会性人类病原体，可引起李斯特菌病，主要影响免疫功能低下者、老年人、婴儿和孕妇。自首次食源性暴发以来的过去 25 年中，李斯特菌病的发病率越来越高。目前，李斯特菌病的治疗主要包括支持治疗和静脉内使用抗生素。抗生素已经商业化 60 多年，用于治疗多种临床疾病。在同一时期，细菌对抗生素的耐药性也在不断发展。本综述旨在阐明单增李斯特菌的抗生素耐药程度、可能的传播机制以及李斯特菌属中抗生素耐药性分布的相关因素，以及可能的控制策略。
