Wang L Q
Department of Pathology, Beijing Medical University.
Zhonghua Bing Li Xue Za Zhi. 1990 Mar;19(1):46-9.
This experiment was designed to observe the effects of 3 ppm and 6 ppm selenium in water on preneoplastic lesions in liver and hepatocarcinogenesis induced by AFB1. In the group administered selenium, the number of hyperplastic foci and enzyme altered foci was much less than that in the AFB1 group. From the 52nd to 79th week, cancers were observed in 11 of 18 rats in the AFB1 group, while none was found in the selenium treated groups. These results reveal that selenium can inhibit the formation of hyperplastic foci and enzyme--altered foci as well as hepatocarcinogenesis induced by AFB1, but selenium can neither prevent the enlargement nor accelerate the regression of the foci already developed after administration of carcinogens. Additionally, toxic effect of selenium was found in 6 ppm selenium group; the number and size of foci were greater in 6 ppm selenium group than those in 3 ppm group. Therefore, adequate amount of selenium is probably the link to achieve better inhibitory effect.
本实验旨在观察水中3 ppm和6 ppm硒对黄曲霉毒素B1（AFB1）诱导的肝脏癌前病变和肝癌发生的影响。在给予硒的组中，增生灶和酶改变灶的数量远少于AFB1组。从第52周到第79周，AFB1组18只大鼠中有11只观察到癌症，而硒处理组未发现癌症。这些结果表明，硒可以抑制增生灶和酶改变灶的形成以及AFB1诱导的肝癌发生，但硒既不能阻止已形成的病灶在给予致癌物后扩大，也不能加速其消退。此外，在6 ppm硒组中发现了硒的毒性作用；6 ppm硒组中病灶的数量和大小均大于3 ppm组。因此，适量的硒可能是实现更好抑制效果的关键环节。
