Bucheli Peter, Vidal Karine, Shen Lisong, Gu Zhencheng, Zhang Charlie, Miller Larry E, Wang Junkuan
Manufacturing Support Department, Nestlé Product Technology Center, Konolfingen, Switzerland.
Optom Vis Sci. 2011 Feb;88(2):257-62. doi: 10.1097/OPX.0b013e318205a18f.
Goji berry (Lycium barbarum L.) is purported to benefit vision because of its high antioxidant (especially zeaxanthin) content, although this effect has not been demonstrated in high-quality human studies. The purpose of this study was to evaluate the effects of daily supplementation with a proprietary milk-based formulation of goji berry, Lacto-Wolfberry (LWB), on macular characteristics and plasma zeaxanthin and antioxidant capacity levels in elderly subjects.
This was a double-masked, randomized, placebo-controlled trial in healthy elderly subjects (range, 65 to 70 years) receiving 13.7 g/d of LWB (n = 75) or placebo (n = 75) for 90 days. Subjects underwent direct ophthalmic examination to assess pigmentation and soft drusen count in the macula and a blood draw to measure plasma zeaxanthin level and total antioxidant capacity.
The placebo group demonstrated hypopigmentation and soft drusen accumulation in the macula, whereas the LWB group remained stable. Both plasma zeaxanthin level and antioxidant capacity increased significantly in the LWB group, by 26% and 57%, respectively, but did not change in the placebo group. No product-related adverse events were reported in either group.
Overall, daily dietary supplementation with goji berry for 90 days increases plasma zeaxanthin and antioxidant levels as well as protects from hypopigmentation and soft drusen accumulation in the macula of elderly subjects. However, the mechanism of action is unclear, given the lack of relationship between change in plasma zeaxanthin and change in macular characteristics.
枸杞（宁夏枸杞）因其高抗氧化剂（尤其是玉米黄质）含量而据称对视力有益，尽管这种效果尚未在高质量的人体研究中得到证实。本研究的目的是评估每日补充一种基于牛奶的专利枸杞配方产品——枸杞乳（LWB）对老年受试者黄斑特征、血浆玉米黄质和抗氧化能力水平的影响。
这是一项双盲、随机、安慰剂对照试验，纳入了65至70岁的健康老年受试者，其中75名受试者每日服用13.7克LWB，75名受试者服用安慰剂，为期90天。受试者接受直接眼科检查以评估黄斑色素沉着和软性玻璃膜疣计数，并进行血液检测以测量血浆玉米黄质水平和总抗氧化能力。
安慰剂组黄斑出现色素减退和软性玻璃膜疣积累，而LWB组保持稳定。LWB组的血浆玉米黄质水平和抗氧化能力均显著增加，分别增加了26%和57%，而安慰剂组则无变化。两组均未报告与产品相关的不良事件。
总体而言，老年受试者每日补充枸杞90天可提高血浆玉米黄质和抗氧化水平，并防止黄斑色素减退和软性玻璃膜疣积累。然而，鉴于血浆玉米黄质变化与黄斑特征变化之间缺乏关联，其作用机制尚不清楚。
