Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 6th People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China.
Med Sci Monit. 2011 Jan;17(1):CR9-13. doi: 10.12659/msm.881318.
Glycemic variability is increasingly recognized as an important issue in diabetes management. However, the lack of normative values may limit its applicability in the clinical setting. The objective of this study was to establish preliminary normal reference ranges for glycemic variability by analyzing continuous glucose monitoring (CGM) data obtained from healthy Chinese adults.
MATERIAL/METHODS: Three-day CGM data were obtained from 434 healthy adults at 10 academic hospitals throughout China. Glycemic variability was calculated as the 24-hour mean amplitude of glycemic excursions (MAGE) and standard deviations (SD) of blood glucose readings.
434 healthy subjects (male 213, female 221; age 43 ± 14, 20-69 years old; BMI 21.8 ± 1.7 kg/m2, 18.5-24.9 kg/m2) completed the study. MAGE and SD values for the 434 healthy subjects were 1.73 (1.08) mmol/L and 0.75 (0.42) mmol/L [median (interquartile range)], respectively. In both men and women, MAGE and SD tended to increase with age. Neither MAGE nor SD showed a significant difference between men and women. Values for both parameters were non-normally distributed within the population. The 95th percentiles of MAGE and SD were 3.86 and 1.40 mmol/L, respectively. These values were adopted as the upper limits of normal.<
MAGE <3.9 mmol/L and SD <1.4 mmol/L are recommended as the normal reference ranges for glycemic variability in Chinese adults. The values established in this study may facilitate the adoption of glycemic variability as a metric of overall glycemic control in diabetes.
血糖变异性在糖尿病管理中日益受到重视。然而，缺乏正常值可能限制了其在临床环境中的应用。本研究旨在通过分析来自中国健康成年人的连续血糖监测（CGM）数据，建立血糖变异性的初步正常参考范围。
在中国 10 家学术医院招募了 434 名健康成年人，进行为期 3 天的 CGM 数据采集。血糖变异性用 24 小时平均血糖波动幅度（MAGE）和血糖读数标准差（SD）来计算。
434 名健康受试者（男性 213 名，女性 221 名；年龄 43 ± 14 岁，20-69 岁；BMI 21.8 ± 1.7 kg/m2，18.5-24.9 kg/m2）完成了研究。434 名健康受试者的 MAGE 和 SD 值分别为 1.73（1.08）mmol/L 和 0.75（0.42）mmol/L[中位数（四分位数间距）]。无论男性还是女性，MAGE 和 SD 均随年龄增长而升高。男性和女性的 MAGE 和 SD 均无显著差异。这两个参数在人群中的分布均为非正态。MAGE 和 SD 的第 95 百分位数分别为 3.86 和 1.40 mmol/L，分别作为正常值上限。
推荐 MAGE<3.9 mmol/L 和 SD<1.4 mmol/L 作为中国成年人血糖变异性的正常参考范围。本研究建立的正常值有助于将血糖变异性作为糖尿病整体血糖控制的指标。
