Genes to Cognition Programme, Wellcome Trust Sanger Institute, Genome Campus, Hinxton, Cambridgeshire, UK.
Nat Neurosci. 2011 Jan;14(1):19-21. doi: 10.1038/nn.2719. Epub 2010 Dec 19.
We isolated the postsynaptic density from human neocortex (hPSD) and identified 1,461 proteins. hPSD mutations cause 133 neurological and psychiatric diseases and were enriched in cognitive, affective and motor phenotypes underpinned by sets of genes. Strong protein sequence conservation in mammalian lineages, particularly in hub proteins, indicates conserved function and organization in primate and rodent models. The hPSD is an important structure for nervous system disease and behavior.
我们从人类新皮层中分离出突触后密度（hPSD），并鉴定出 1461 种蛋白质。hPSD 突变导致 133 种神经和精神疾病，并富集在认知、情感和运动表型中，这些表型由一系列基因支持。哺乳动物谱系中蛋白质序列的高度保守性，特别是在枢纽蛋白中，表明在灵长类动物和啮齿类动物模型中存在保守的功能和组织。hPSD 是神经系统疾病和行为的重要结构。
