Hanchanale Vishwanath S, McCabe John E, Javlé Pradip
Department of Urology, Leighton Hospital, Crewe, United Kingdom, CW1 4QJ, UK. vishwanath.
Urol J. 2010 Fall;7(4):243-8.
As there is paucity of data on radical prostatectomy (RP) as a primary treatment for patients with localized prostate cancer, we analyzed the trends in the RP practice in England.
This study was carried out on 14 300 patients who underwent RP for carcinoma of the prostate. Database was prepared from hospital episode statistics of the Department of Health in England. National trends in RP practice were summarized as well as volume outcome analysis.
Annual number of RPs exponentially increased from 972 (1998 to 1999) to 3092 (2004 to 2005). Laparoscopic RPs increased from 2 to 257 over the study period. Median waiting duration increased by more than 10 days (13 days). Significant decrease in median length of hospital stay from 8 (range, 7 to 10) days to 6 (range, 5 to 8) days was observed (P < .001). More than 90% mortality was seen in patients of ≥ 60 years of age. Significant inverse correlation was found between the hospital volume (Odds Ratio: 0.40) and in-hospital mortality rate following RP. High volume surgeons (≥ 16) and high volume hospitals (≥ 26) had significantly lower mortality (Odds Ratio: 0.32) and shorter in-hospital stay in comparison to low volume surgeons and hospitals.
There is an exponential increase in the number of RPs with an increasing trend towards laparoscopic RP in England. This study showed a significant inverse correlation between provider volume (hospital and surgeon) and outcome (in-hospital mortality and hospital stay) for RP in England; thus, supporting the recommendations for centralization of care for complex radical procedures, including RP.
鉴于关于根治性前列腺切除术(RP)作为局限性前列腺癌患者主要治疗方法的数据较少,我们分析了英格兰RP手术的趋势。
本研究对14300例行前列腺癌RP手术的患者进行。数据库由英格兰卫生部的医院事件统计数据编制而成。总结了RP手术的全国趋势以及手术量与结果分析。
RP手术的年度数量从1998年至1999年的972例呈指数增长至2004年至2005年的3092例。在研究期间,腹腔镜RP手术从2例增加到257例。中位等待时间增加了超过10天(13天)。观察到中位住院时间从8天(范围7至10天)显著缩短至6天(范围5至8天)(P <.001)。≥60岁患者的死亡率超过90%。发现医院手术量(优势比:0.40)与RP术后院内死亡率之间存在显著负相关。与低手术量的外科医生和医院相比,高手术量的外科医生(≥16例)和高手术量的医院(≥26例)的死亡率显著更低(优势比:0.32)且住院时间更短。
在英格兰,RP手术数量呈指数增长,且腹腔镜RP手术有增加趋势。本研究表明,在英格兰,医疗服务提供者的手术量(医院和外科医生)与RP手术的结果(院内死亡率和住院时间)之间存在显著负相关;因此,支持对包括RP在内的复杂根治性手术进行集中治疗的建议。