Li Xu-sheng, Chen Guo-rong, Li Jian-ming, Hu Yun, Wang Fang, Hu Ye
Medical College, Jinhua College of Profession and Technology, Jinhua 321000, China.
Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2005 May;21(2):176-8.
To study the protective effect of Gingko biloba extract (EGb) against myocardial impairment in diabetic rats.
Morphology of effect of EGb on myocardium in diabetic rats was observed under light microscopy (LM) and transmission electron microscopy (TEM). Activity of super oxide dismutase (SOD), nitric oxide synthase (NOS), constitutive nitric oxide synthase (cNOS), inductive nitric oxide synthase (iNOS) and content of malondialdehyde (MDA), nitric oxide (NO) were detected biochemically in myocardial homogenate.
It was manifestation as vascular degeneration and local lysis of myocardial fiber under LM and swelling of mitochondria, shorten of mitochondrial crest, lysis of myofibril under TEM, the activity of SOD decreased and the activity of NOS, iNOS, the content of NO, MDA increased, but the morphological changes became slight in EGb treatment group. Activity of SOD increased while activity of NOS, iNOS and content of MDA, NO decreased in EGb treatment group compared with diabetic group.
EGb can protect diabetic myocardium and anti-lipid peroxidation and decrease of NO level may be involved in it.
研究银杏叶提取物（EGb）对糖尿病大鼠心肌损伤的保护作用。
在光学显微镜（LM）和透射电子显微镜（TEM）下观察EGb对糖尿病大鼠心肌的影响形态。采用生化方法检测心肌匀浆中超氧化物歧化酶（SOD）、一氧化氮合酶（NOS）、组成型一氧化氮合酶（cNOS）、诱导型一氧化氮合酶（iNOS）的活性以及丙二醛（MDA）、一氧化氮（NO）的含量。
光镜下表现为血管变性和心肌纤维局部溶解，电镜下可见线粒体肿胀、嵴缩短、肌原纤维溶解，糖尿病组SOD活性降低，NOS、iNOS活性及NO、MDA含量升高，而EGb治疗组形态学改变减轻。与糖尿病组相比，EGb治疗组SOD活性升高，NOS、iNOS活性及MDA、NO含量降低。
EGb可保护糖尿病心肌，其机制可能与抗脂质过氧化及降低NO水平有关。
