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呼吸道疾病中细菌提取物的免疫调节作用

Immunomodulation with bacterial extracts in respiratory diseases.

作者信息

Palma-Carlos A G, Palma-Carlos M L

机构信息

Center of Hematology and Immunology (INIC), Faculty of Medicine, Lisbon, Portugal.

出版信息

Lung. 1990;168 Suppl:732-6. doi: 10.1007/BF02718201.

DOI:10.1007/BF02718201
PMID:2117185
Abstract

A lyophilized bacterial extract (Broncho-Vaxom) has been studied in a large number of models and found to induce specific and nonspecific responses by oral administration. It stimulates the systemic and local immune response. It activates the macrophages that play a key part in the immune system, modulates the immunoglobulin level, and potentiates the lymphocyte response to phytohemagglutinin (PHA) and other mitogens. The effect of this bacterial extract on T-lymphocyte subpopulations is currently under study.

摘要

一种冻干细菌提取物(支气管疫苗)已在大量模型中进行了研究,发现口服给药可诱导特异性和非特异性反应。它能刺激全身和局部免疫反应。它激活在免疫系统中起关键作用的巨噬细胞,调节免疫球蛋白水平,并增强淋巴细胞对植物血凝素(PHA)和其他有丝分裂原的反应。这种细菌提取物对T淋巴细胞亚群的影响目前正在研究中。

相似文献

1
Immunomodulation with bacterial extracts in respiratory diseases.呼吸道疾病中细菌提取物的免疫调节作用
Lung. 1990;168 Suppl:732-6. doi: 10.1007/BF02718201.
2
Non specific immunomodulation in respiratory infections.呼吸道感染中的非特异性免疫调节
Allerg Immunol (Paris). 1990 May;22(5):179, 181-5.
3
[Recurrent respiratory tract infections. Treatment by oral immunostimulation with Broncho-Vaxom].
Fortschr Med. 1987 Mar 30;105(9):176-80.
4
Immunotherapy with an oral bacterial extract (OM-85 BV) for upper respiratory infections.使用口服细菌提取物(OM-85 BV)治疗上呼吸道感染的免疫疗法。
Respiration. 1991;58(3-4):150-4. doi: 10.1159/000195916.
5
Effect of oral bacterial lysates on serum immunoglobulins.口服细菌裂解物对血清免疫球蛋白的影响。
Allerg Immunol (Paris). 1989 Nov;21(9):354-6.
6
Preventive effects of an immunostimulating product on recurrent infections of chronic bronchitis in the elderly.
Lung. 1990;168 Suppl:737-40. doi: 10.1007/BF02718202.
7
Immunomodulation of allergic autocytotoxicity in bronchial asthma by a bacterial lysate--Broncho-Vaxom.细菌溶解产物——泛福舒对支气管哮喘中过敏性自身细胞毒性的免疫调节作用
Int J Immunopharmacol. 1985;7(5):713-8. doi: 10.1016/0192-0561(85)90156-0.
8
Bacterial immunostimulant (Broncho-Vaxom) versus levamisole on the humoral immune response in mice.
J Immunopharmacol. 1983;5(1-2):107-16. doi: 10.3109/08923978309026446.
9
[Broncho-Vaxom in the treatment of recurrent respiratory tract infections in children].
Pneumonol Pol. 1986 Jun;54(6):231-5.
10
A bacterial extract of OM-85 Broncho-Vaxom prevents allergic rhinitis in mice.OM-85 Broncho-Vaxom的细菌提取物可预防小鼠过敏性鼻炎。
Am J Rhinol Allergy. 2014 Mar-Apr;28(2):110-6. doi: 10.2500/ajra.2013.27.4021.

引用本文的文献

1
Intranasal immunization with a colloid-formulated bacterial extract induces an acute inflammatory response in the lungs and elicits specific immune responses.用胶体形式配制的细菌提取物进行鼻内免疫会在肺部引发急性炎症反应并引发特异性免疫反应。
Infect Immun. 2004 May;72(5):2679-88. doi: 10.1128/IAI.72.5.2679-2688.2004.
2
The polybacterial lysate Olimunostim modulates lymphocyte function in vitro and restores depressed cellular immunity in vivo.多细菌裂解物Olimunostim在体外调节淋巴细胞功能,并在体内恢复受抑制的细胞免疫。
Folia Microbiol (Praha). 1994;39(5):435-40. doi: 10.1007/BF02814452.

本文引用的文献

1
Immunoglobulin production in man stimulated by an orally administered bacterial lysate.口服细菌裂解物刺激人体产生免疫球蛋白。
Respiration. 1980;40(3):142-9. doi: 10.1159/000194264.
2
Bacterial immunostimulant (Broncho-Vaxom) versus levamisole on the humoral immune response in mice.
J Immunopharmacol. 1983;5(1-2):107-16. doi: 10.3109/08923978309026446.
3
[Effect of an oral polyvalent bacterial lysate (Broncho-Vaxom) in chronic bronchitis].
Prax Klin Pneumol. 1984 Jun;38(6):225-8.
4
Clinical and immunobiological effects of an orally administered bacterial extract.口服细菌提取物的临床和免疫生物学效应。
Int J Immunopharmacol. 1984;6(2):111-7. doi: 10.1016/0192-0561(84)90005-5.
5
Oral immunotherapy of chronic bronchitis: a double-blind placebo-controlled multicentre study.慢性支气管炎的口服免疫疗法:一项双盲安慰剂对照多中心研究。
Respiration. 1989;55(3):129-35. doi: 10.1159/000195723.
6
Activation of natural killer cells and cytokine production in man by bacterial extracts.细菌提取物对人体自然杀伤细胞的激活及细胞因子的产生
Immunopharmacol Immunotoxicol. 1989;11(1):17-32. doi: 10.3109/08923978909082140.