Debbas N, Derenne J P
Centre de Recherche des Laboratoires Fournier, Dijon, France.
Lung. 1990;168 Suppl:737-40. doi: 10.1007/BF02718202.
The effect of an immunostimulating drug, OM-85 BV, was demonstrated on recurrent infection rates in 265 elderly patients with a defined state of chronic bronchitis, during a 6-month, double-blind, placebo-controlled trial. Patients receiving OM-85 BV presented less infections (p = 0.005) and a significantly reduced intake of antibiotics (p = 0.02) as compared to those receiving a placebo and the antibiotic intake was significantly reduced (p = 0.02).