Wybran J, Libin M, Schandene L
Department of Immunology, Hematology and Transfusion, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
Immunopharmacol Immunotoxicol. 1989;11(1):17-32. doi: 10.3109/08923978909082140.
Broncho-Vaxon (OM-85 BV) is a bacterial extract of eight bacterias usually involved in the respiratory tract infections. Since Broncho-Vaxom is clinically active in decreasing the incidence of such infections, its immunological effect was investigated, in vitro, using peripheral blood mononuclear cells (PBMC). The experimental data indicate that Broncho-Vaxom can modulate various immune functions. It was shown, using a radioimmunoassay for these cytokines, that Broncho-Vaxom will spontaneously enhance TNF alpha and IL-2 production whereas it has no action on IF gamma production. However, when the PBMC are stimulated with PHA, an increased production for IF gamma, TNF alpha and IL-2 was observed suggesting that, under appropriate conditions, Broncho-Vaxom enhances the production of these cytokines. In other experiments, Broncho-Vaxom was shown to markedly increase the natural killer activity of PBMC. All these results demonstrate that Broncho-Vaxom is an immunomodulator affecting multiple immunological mechanisms including the activation of natural killer cells, of monocytes and of T cells through direct mechanisms or through the cytokine cascade.
泛福舒（OM-85 BV）是一种由通常与呼吸道感染相关的8种细菌制成的细菌提取物。由于泛福舒在临床上可有效降低此类感染的发生率，因此利用外周血单核细胞（PBMC）在体外研究了其免疫效应。实验数据表明，泛福舒可调节多种免疫功能。使用针对这些细胞因子的放射免疫分析法显示，泛福舒可自发增强肿瘤坏死因子α（TNFα）和白细胞介素-2（IL-2）的产生，而对干扰素γ（IFγ）的产生无作用。然而，当用植物血凝素（PHA）刺激PBMC时，观察到IFγ、TNFα和IL-2的产生增加，这表明在适当条件下，泛福舒可增强这些细胞因子的产生。在其他实验中，泛福舒被证明可显著提高PBMC的自然杀伤活性。所有这些结果表明，泛福舒是一种免疫调节剂，可通过直接机制或细胞因子级联反应影响多种免疫机制，包括激活自然杀伤细胞、单核细胞和T细胞。
