Levi-Valensi P, Aubry P, Rida Z
Unité de Réanimation Resp., Hôpital Sud, Amiens, France.
Lung. 1990;168 Suppl:770-5. doi: 10.1007/BF02718206.
Six European treatment centers contributed to a controlled trial to study nocturnal hypoxemia in COPD patients having daytime PaO2 of 60-70 mmHg. The trial is composed of two parts: first, patients inclusion, taking men aged under 70 years, excluding sleep apnea syndrome and all other concomitant pathologies leading to nocturnal desaturation. We described this population and determined the frequency and degree of nocturnal desaturation. Correlations between different daytime and sleep parameters have also been established. The second part concerns the study of the two sub-populations of nocturnal desaturators and nondesaturators. This is followed by random allocation of the desaturators to oxygen or no oxygen treatment. We defined significant nocturnal desaturation as cumulated unsaturation period, exceeding 30% of total time, in bed spent under SaO2 lower than 90%. Twenty out of 46 patients were desaturators (43%). Only the first part is dealt with in this article.
六个欧洲治疗中心参与了一项对照试验，以研究白天动脉血氧分压（PaO2）为60 - 70 mmHg的慢性阻塞性肺疾病（COPD）患者的夜间低氧血症。该试验由两部分组成：首先，纳入患者，纳入年龄在70岁以下的男性，排除睡眠呼吸暂停综合征以及所有其他导致夜间血氧饱和度下降的伴随疾病。我们描述了这一人群，并确定了夜间血氧饱和度下降的频率和程度。还建立了不同白天和睡眠参数之间的相关性。第二部分涉及对夜间血氧饱和度下降者和非下降者这两个亚组人群的研究。随后将血氧饱和度下降者随机分配接受吸氧或不吸氧治疗。我们将显著夜间血氧饱和度下降定义为累积未饱和时间段超过总卧床时间的30%，且血氧饱和度（SaO2）低于90%。46名患者中有20名是血氧饱和度下降者（43%）。本文仅涉及第一部分内容。
