Department of Gastroenterology and Liver Diseases, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 6 Weizman Street, Tel Aviv, 64239 Israel.
J Crohns Colitis. 2008 Dec;2(4):310-4. doi: 10.1016/j.crohns.2008.05.001. Epub 2008 Jun 25.
It is not clear whether Crohn's disease patients in clinical remission (Crohn's disease activity index<150) display normal concentrations of inflammation sensitive biomarkers. Our goal in this work was to explore the intensity of the microinflammatory response in a group of Crohn's disease patients in clinical remission.
High sensitivity C-reactive protein, quantitative fibrinogen, erythrocyte sedimentation rate as well as platelet and leukocyte counts were examined in a group of 76 patients with Crohn's disease in remission and in 228 matched controls.
Crohn's disease patients in clinical remission displayed a statistically significant (p<0.001) elevated concentration of hs-CRP (4.83±3.8 mg/l) compared to controls (1.05±2.9 mg/l). All other bio-markers were also significantly higher in Crohn's disease patients in remission compared to controls. Similar results were obtained in a subgroup of Crohn's disease patients with very low disease activity - CDAI<75.
Clinical remission is not equivalent to biochemical remission raising a question concerning the true definition of remission in Crohn's disease.
尚不清楚处于临床缓解期（克罗恩病活动指数<150）的克罗恩病患者是否表现出正常浓度的炎症敏感生物标志物。我们在这项工作中的目标是探讨一组处于临床缓解期的克罗恩病患者的微炎症反应强度。
我们检查了 76 例处于缓解期的克罗恩病患者和 228 名匹配对照者的高敏 C 反应蛋白、定量纤维蛋白原、红细胞沉降率以及血小板和白细胞计数。
与对照组（1.05±2.9 mg/l）相比，处于临床缓解期的克罗恩病患者的 hs-CRP（4.83±3.8mg/l）浓度显著升高（p<0.001）。与对照组相比，所有其他生物标志物在缓解期的克罗恩病患者中也显著升高。在疾病活动度非常低的克罗恩病患者亚组（CDAI<75）中也获得了类似的结果。
临床缓解并不等同于生化缓解，这引发了对克罗恩病缓解真正定义的质疑。
