TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Nat Rev Cardiol. 2011 Mar;8(3):140-7. doi: 10.1038/nrcardio.2010.199. Epub 2010 Dec 21.
The clinical entities that comprise acute coronary syndromes (ACS)-ST-segment elevation myocardial infarction (STEMI), non-STEMI, and unstable angina-have been recognized as widespread causes of death and disability for more than a century. Seminal research in the past 50 years has led to important scientific and medical advances in our understanding of ACS. Rapid modernization of the developing world has led to a pandemic of coronary artery disease and its manifestation as ACS, with profound implications for personal, societal, and global health. Epidemiological studies have provided insight into the changing demographics of ACS, and highlighted the importance of modifiable risk factors and adherence to guideline-recommended therapy.
急性冠状动脉综合征（ACS）包括 ST 段抬高型心肌梗死（STEMI）、非 ST 段抬高型心肌梗死和不稳定型心绞痛，这些临床实体在一个多世纪以来一直被认为是导致死亡和残疾的广泛原因。过去 50 年来的开创性研究使我们对 ACS 的认识取得了重要的科学和医学进步。发展中国家的快速现代化导致了冠状动脉疾病的流行及其表现为 ACS，这对个人、社会和全球健康都产生了深远的影响。流行病学研究深入了解了 ACS 的人口统计学变化，并强调了可改变的危险因素和遵循指南推荐治疗的重要性。
