School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UK.
Chem Commun (Camb). 2011 Mar 7;47(9):2589-91. doi: 10.1039/c0cc04795c. Epub 2010 Dec 21.
A CuAAC reaction was established for modular synthesis of end-stapled homo- and hetero-triple helical peptides, generating "clicked" macro-assemblies with enhanced thermal stability.
建立了一个 CuAAC 反应,用于末端钉合的同型和异型三螺旋肽的模块化合成,生成了具有增强热稳定性的“点击”的大环组装体。