The Warren and Katharine Schlinger Laboratory for Chemistry and Chemical Engineering, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
J Am Chem Soc. 2011 Feb 2;133(4):774-6. doi: 10.1021/ja110192b.
An enantioselective total synthesis of the diterpenoid natural product (+)-salvileucalin B is reported. Key findings include a copper-catalyzed arene cyclopropanation reaction to provide the unusual norcaradiene core and a reversible retro-Claisen rearrangement of a highly functionalized norcaradiene intermediate.
报道了二萜类天然产物(+)-salvileucalin B 的对映选择性全合成。关键发现包括铜催化的芳环环丙烷化反应，提供了不寻常的降蒈烯核，以及高度官能化的降蒈烯中间体的可逆逆-Claisen 重排。
