Rusterholz Corinne, Messerli Marianne, Hoesli Irene, Hahn Sinuhe
Laboratory for Prenatal Medicine, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Hypertens Pregnancy. 2011;30(3):364-75. doi: 10.3109/10641951003599571. Epub 2010 Dec 21.
Preeclampsia is a common disorder of the second half of pregnancy that complicates 2% to 7% of all pregnancies worldwide and remains a major cause of maternal and fetal morbidity and mortality. Although the origin of the disease is still elusive, population-based studies have suggested that it might implicate genetic, immunologic, or physiologic factors. On the other hand, there is no doubt that the placenta plays an important role in its development. In preeclampsia, the shedding of placenta debris, such as syncytiotrophoblast microparticles (STBMs) and DNA and messenger RNA molecules, into the maternal peripheral blood is increased. The analysis of this material may give new insight into placentation and the underlying etiology of this disorder, as well as yield new tracks of research for the understanding of the molecular mechanisms, leading to the generation of the clinical symptoms.
子痫前期是妊娠后半期常见的病症，在全球所有妊娠中，有2%至7%会出现这种并发症，它仍是孕产妇和胎儿发病及死亡的主要原因。尽管该疾病的病因仍不明确，但基于人群的研究表明，其可能涉及遗传、免疫或生理因素。另一方面，胎盘在其发病过程中无疑起着重要作用。在子痫前期，胎盘碎片（如合体滋养层微粒、DNA和信使RNA分子）进入母体外周血的量会增加。对这些物质的分析可能会为胎盘形成及该病症的潜在病因提供新的见解，也能为理解导致临床症状产生的分子机制提供新的研究线索。
