Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Mol Biol Rep. 2013 Jul;40(7):4553-9. doi: 10.1007/s11033-013-2536-0. Epub 2013 May 6.
Preeclampsia (PE) is a syndrome characterized by poor placentation and endothelial dysfunction. The diagnosis for this syndrome is based in hypertension and proteinuria presented after the 20th week of pregnancy. Despite intensive research, PE is still one of the leading causes of maternal mortality, although reliable screening tests or effective treatments of this disease have yet to be proposed. Microparticles (MPs) are small vesicles released after cell activation or apoptosis, which contain membrane proteins that are characteristic of the original parent cell. MPs have been proven to play key role in thrombosis, inflammation, and angiogenesis, as well as to mediate cell-cell communication by transferring mRNAs and microRNA from the cell of origin to target cells. Placenta-derived syncytiotrophoblast MPs are one of the most increased MPs during PE and may play an important role in the pathogenesis of this syndrome. Therefore, a better overall understanding of the role of MPs in PE may be useful for new clinical diagnoses and therapeutic approaches.
子痫前期（PE）是一种以胎盘功能不良和血管内皮功能障碍为特征的综合征。该综合征的诊断基于妊娠 20 周后出现的高血压和蛋白尿。尽管进行了深入研究，但子痫前期仍然是孕产妇死亡的主要原因之一，尽管尚未提出可靠的筛查测试或有效的治疗方法。微颗粒（MPs）是细胞激活或凋亡后释放的小囊泡，其中包含有特征性的原始亲本细胞的膜蛋白。MPs 已被证明在血栓形成、炎症和血管生成中发挥关键作用，并通过将 mRNAs 和 microRNA 从起源细胞转移到靶细胞来介导细胞间通讯。胎盘来源的合体滋养层 MPs 是子痫前期中增加最多的 MPs 之一，可能在该综合征的发病机制中发挥重要作用。因此，更好地理解 MPs 在 PE 中的作用可能有助于新的临床诊断和治疗方法。
