Thrombosis and Hemostasis Unit, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel.
Thromb Res. 2011 Feb;127 Suppl 3:S67-71. doi: 10.1016/S0049-3848(11)70019-6.
Microparticles (MPs) are shed from cell membranes of a variety of cells, promote thrombus formation, mediate pro-inflammatory effects and may cause endothelial dysfunction. Normal pregnancy is characterized by increased levels of MPs compared to non-pregnant healthy women but the prevalence, cell origin and the role of MPs in pregnancy-related complications remain controversial. Normal pregnancy is an acquired hyper-coagulable state due to an increase in procoagulants and decrease in natural anticoagulants. Pregnancy-related complications such as preeclampsia, intrauterine fetal growth restriction (IUGR) and fetal loss are associated with placental dysfunction and may cause significant maternal and fetal morbidity and mortality. This article highlights the role of microparticles in maternal placental crosstalk and the interplay between microparticles, thrombosis and pregnancy complications.
微粒（MPs）从各种细胞的细胞膜脱落，促进血栓形成，介导促炎作用，并可能导致内皮功能障碍。与非妊娠健康女性相比，正常妊娠的 MPs 水平升高，但 MPs 在妊娠相关并发症中的患病率、细胞来源和作用仍存在争议。正常妊娠是一种获得性高凝状态，由于促凝物质增加和天然抗凝物质减少。子痫前期、宫内胎儿生长受限（IUGR）和胎儿丢失等妊娠相关并发症与胎盘功能障碍有关，可能导致母体和胎儿发病率和死亡率显著增加。本文重点介绍微粒在母体胎盘串扰中的作用以及微粒、血栓形成和妊娠并发症之间的相互作用。
