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色素沉着与困境：一例与卡培他滨使用相关的手足综合征病例报告

Discoloration and Dilemma: A Case Report of Hand-Foot Syndrome Associated With Capecitabine Use.

作者信息

Gohil Rucha, Bojanapati Kalyan, Reddy Keerthi, Kumar Kavin, Kumar J

机构信息

General Medicine, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology (SRMIST), Chengalpattu, IND.

出版信息

Cureus. 2024 Jul 22;16(7):e65151. doi: 10.7759/cureus.65151. eCollection 2024 Jul.

DOI:10.7759/cureus.65151
PMID:39176371
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11341071/
Abstract

This case highlights the occurrence of hand-foot syndrome due to the use of an antimetabolite group of drugs, capecitabine, which was used in the chemotherapy of a 56-year-old male patient who was diagnosed with rectosigmoid carcinoma. The patient was diagnosed with rectosigmoid carcinoma two months ago and underwent laparoscopic lower anterior resection and colorectal anastomosis. Subsequently, the patient commenced chemotherapy treatment with a combination of oxaliplatin and capecitabine. The patient presented to us with complaints of loose stools for the past three days, and discoloration of the palms, soles, and tongue was noted and subjected to a biopsy, which revealed features compatible with chronic, nonspecific dermatitis. The occurrence of such palmar-plantar erythrodysesthesia with capecitabine is yet to be extensively studied.

摘要

该病例突出了因使用抗代谢类药物卡培他滨而发生的手足综合征，该药物用于一名56岁男性直肠癌乙状结肠癌患者的化疗。患者两个月前被诊断为直肠癌乙状结肠癌，并接受了腹腔镜下低位前切除术和结直肠吻合术。随后，患者开始接受奥沙利铂和卡培他滨联合化疗。患者向我们诉说过去三天有腹泻症状，并且发现手掌、脚底和舌头变色，接受活检后显示为符合慢性非特异性皮炎的特征。卡培他滨引起的这种手足红斑感觉异常的情况尚未得到广泛研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/ea2a09e877a2/cureus-0016-00000065151-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/0a1e55c5c443/cureus-0016-00000065151-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/8e82c85aa205/cureus-0016-00000065151-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/ea2a09e877a2/cureus-0016-00000065151-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/0a1e55c5c443/cureus-0016-00000065151-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/8e82c85aa205/cureus-0016-00000065151-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f21/11341071/ea2a09e877a2/cureus-0016-00000065151-i03.jpg

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本文引用的文献

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Predictive factors for the development of capecitabine-induced hand-foot syndrome: a retrospective observational cohort study.卡培他滨所致手足综合征发生的预测因素：一项回顾性观察队列研究。
Ann Med Surg (Lond). 2023 Nov 7;86(1):73-77. doi: 10.1097/MS9.0000000000001487. eCollection 2024 Jan.
2
Capecitabine-induced oral mucosal hyperpigmentation associated with hand-foot syndrome - A literature review.卡培他滨引起的口腔黏膜过度色素沉着与手足综合征相关：文献综述。
An Bras Dermatol. 2023 May-Jun;98(3):302-309. doi: 10.1016/j.abd.2022.05.004. Epub 2023 Feb 17.
3
Hand-Foot Syndrome Presentation Post-Capecitabine Treatment in a Black Patient.
一名黑人患者接受卡培他滨治疗后的手足综合征表现
Cureus. 2022 Jul 15;14(7):e26891. doi: 10.7759/cureus.26891. eCollection 2022 Jul.
4
Study protocol of a single-arm phase 2 study evaluating the preventive effect of topical hydrocortisone for capecitabine-induced hand-foot syndrome in colorectal cancer patients receiving adjuvant chemotherapy with capecitabine plus oxaliplatin (T-CRACC study).一项单臂 2 期研究的研究方案，评估局部氢化可的松预防卡培他滨联合奥沙利铂辅助化疗的结直肠癌患者发生卡培他滨诱导的手足综合征的预防作用（T-CRACC 研究）。
BMC Gastroenterol. 2022 Jul 14;22(1):341. doi: 10.1186/s12876-022-02411-w.
5
Randomized double-blind, placebo-controlled study of topical diclofenac in the prevention of hand-foot syndrome in patients receiving capecitabine (the D-TORCH study).卡培他滨治疗患者中双氯芬酸局部预防手足综合征的随机双盲、安慰剂对照研究（D-TORCH 研究）。
Trials. 2022 May 19;23(1):420. doi: 10.1186/s13063-022-06353-2.
6
Do you know this syndrome? Hand-foot syndrome.你知道这种综合征吗？手足综合征。
An Bras Dermatol. 2017 Jan-Feb;92(1):131-133. doi: 10.1590/abd1806-4841.20174602.
7
The contribution of keratinocytes in capecitabine-stimulated hand-foot-syndrome.角质形成细胞在卡培他滨诱发的手足综合征中的作用。
Environ Toxicol Pharmacol. 2017 Jan;49:81-88. doi: 10.1016/j.etap.2016.12.001. Epub 2016 Dec 5.
8
Capecitabine and hand-foot syndrome.卡培他滨与手足综合征。
Expert Opin Drug Saf. 2011 Mar;10(2):159-69. doi: 10.1517/14740338.2011.546342. Epub 2010 Dec 22.
9
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J Oncol Pharm Pract. 2006 Sep;12(3):131-41. doi: 10.1177/1078155206069242.
10
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Clin Pharmacokinet. 2001;40(2):85-104. doi: 10.2165/00003088-200140020-00002.