School of Dentistry, The University of Western Australia.
Aust Dent J. 2010 Dec;55(4):378-84. doi: 10.1111/j.1834-7819.2010.01257.x.
Biopsy of a suspected oral squamous cell carcinoma (SCC) is important for diagnosis. Concerns have been raised about the potential for tumour spread by incisional biopsy techniques. This study aimed to investigate the five-year survival and recurrence of oral SCC after incisional and excisional biopsy in total population data available from the Western Australian Cancer Registry (WACR).
Total population data from the WACR, comprising all primary oral SCC cases diagnosed between 1990 and 1999, were examined. Information extracted included date of birth, gender, biopsy date, biopsy type, disease stage (TNM classification), disease site, date of recurrence and date of death. Records were excluded if the diagnosis was fine needle aspiration based, was not that of oral SCC and if a history was noted of another malignant neoplasm. Incisional and excisional biopsy cases were compared for five-year survival, adjusting for disease stage.
No association was found between biopsy type and five-year survival or recurrence amongst individuals with Stage I or II disease.
In this study, biopsy type was not associated with survival of oral SCC patients with Stage I or II disease, adding to the evidence that incisional biopsy of oral SCC can be a safe procedure.
疑似口腔鳞状细胞癌（SCC）的活组织检查对于诊断很重要。人们对切开活检技术可能导致肿瘤扩散的问题表示担忧。本研究旨在通过西澳大利亚癌症登记处（WACR）的总人群数据，调查口腔 SCC 在切开和切除活检后的五年生存率和复发率。
从 WACR 的总人群数据中，检查了 1990 年至 1999 年间诊断的所有原发性口腔 SCC 病例。提取的信息包括出生日期、性别、活检日期、活检类型、疾病分期（TNM 分类）、疾病部位、复发日期和死亡日期。如果诊断基于细针抽吸、不是口腔 SCC 且记录有另一种恶性肿瘤，则排除记录。对各期疾病患者进行比较，以调整疾病分期来评估五年生存率。
在 I 期或 II 期疾病患者中，活检类型与五年生存率或复发率之间无关联。
在本研究中，活检类型与 I 期或 II 期口腔 SCC 患者的生存率无关，这进一步证明了对口腔 SCC 进行切开活检是一种安全的操作。
