Departments of Medical Microbiology, Crosshouse Hospital, Kilmarnock, Scotland, United Kingdom.
Ann N Y Acad Sci. 2010 Dec;1213:81-91. doi: 10.1111/j.1749-6632.2010.05867.x.
Bacterial resistance to multiple antibiotics is a serious and emerging threat. Several measures have been proposed to curb this growing trend. These include prescribing restrictions, education, and infection control that target transmission, among several others. Antibiotic cycling has been a subject of debate, and although many investigators have studied the utility of antibiotic cycling with the help of theoretical models or as part of clinical investigations, several areas remain undefined and unclear. This review summarizes the available information on antibiotic heterogeneity (antibiotic cycling, antibiotic mixing, and other types of antibiotic protocols) with a critical analysis of the published studies.
细菌对多种抗生素的耐药性是一个严重且日益严重的威胁。已经提出了几种措施来遏制这一不断增长的趋势。这些措施包括限制处方、教育和针对传播的感染控制等。抗生素循环一直是一个有争议的话题，尽管许多研究人员已经借助理论模型或作为临床研究的一部分，对抗生素循环的实用性进行了研究，但仍有几个领域尚未明确和清晰。本综述总结了现有关于抗生素异质性（抗生素循环、抗生素混合和其他类型的抗生素方案）的信息，并对已发表的研究进行了批判性分析。
