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抗生素的使用既能做到公正又能做到可持续……还是只能或多或少做到?

Can antibiotic use be both just and sustainable... or only more or less so?

机构信息

Department of Infection, 3rd Floor, Pathology and Pharmacy Building, 80 Newark Street, Whitechapel, London E1 2ES, UK.

出版信息

J Med Ethics. 2011 Mar;37(3):153-7. doi: 10.1136/jme.2010.038042. Epub 2010 Nov 8.

Abstract

Antibiotic resistance threatens the capacity to treat life-threatening infections. If it is accepted that it will be many years (if not decades) until the production of new antibiotics overcomes current concerns with antibiotic resistance then ways to conserve the effectiveness of current antibiotics will have to be found. For many bacterial agents of infection levels of antibiotic resistance are directly dependent on the quantity of antibiotic prescribed. Antibiotics are currently underutilised in many parts of the world. If a just distribution of access to antibiotics requires equal access for individuals with equal need irrespective of wealth then responding to this requirement of justice has the potential to shorten the effective life of currently available antibiotics. Increasing the range and numbers of individuals treated with antibiotics would seem to threaten sustainability and also potentially undermine the access of future generations to cost-effective treatments for bacterial infection. The control of antibiotic resistance requires that the determinants of infectious disease transmission are addressed, such as poor housing, education and nutrition as well as the provision of antibiotics. The apparent tension between intragenerational justice and sustainability diminishes when the account of distributive justice extends beyond access to antibiotics and includes plural entitlements. Controlling antibiotic resistance requires more than the redistribution or reduction (in the overall use) of antibiotics.

摘要

抗生素耐药性威胁到治疗危及生命的感染的能力。如果人们普遍认为,要生产出克服当前抗生素耐药性问题的新型抗生素,还需要很多年(甚至几十年),那么就必须找到方法来保持现有抗生素的有效性。对于许多感染细菌的病原体,抗生素的耐药性水平直接取决于所开抗生素的剂量。目前,抗生素在世界许多地方都未得到充分利用。如果公平分配抗生素的获取权意味着无论贫富,所有有同等需求的个人都应平等获得抗生素,那么满足这一正义要求可能会缩短现有抗生素的有效使用期限。扩大抗生素治疗的范围和人数,似乎会威胁到可持续性,也可能破坏后代获得针对细菌感染的具有成本效益的治疗方法的机会。控制抗生素耐药性需要解决传染病传播的决定因素,例如住房条件差、教育和营养水平以及抗生素的供应。当分配正义的解释不仅包括获得抗生素的权利,还包括多种权利时,代际间正义和可持续性之间的明显紧张关系就会减少。控制抗生素耐药性需要的不仅仅是抗生素的再分配或减少(整体使用量)。

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