Ferreira Ana Rita, Ramos Bruno, Nunes Alexandre, Ribeiro Daniela
Institute of Biomedicine-iBiMED, Department of Medical Sciences, University of Aveiro, 3810-193 Aveiro, Portugal.
J Clin Med. 2020 Mar 13;9(3):790. doi: 10.3390/jcm9030790.
Hepatitis C virus (HCV) infections constitute a major public health problem and are the main cause of chronic hepatitis and liver disease worldwide. The existing drugs, while effective, are expensive and associated with undesirable secondary effects. There is, hence, an urgent need to develop novel therapeutics, as well as an effective vaccine to prevent HCV infection. Understanding the interplay between HCV and the host cells will certainly contribute to better comprehend disease progression and may unravel possible new cellular targets for the development of novel antiviral therapeutics. Here, we review and discuss the interplay between HCV and the host cell innate immunity. We focus on the different cellular pathways that respond to, and counteract, HCV infection and highlight the evasion strategies developed by the virus to escape this intracellular response.
丙型肝炎病毒（HCV）感染是一个重大的公共卫生问题，是全球慢性肝炎和肝病的主要病因。现有的药物虽然有效，但价格昂贵且伴有不良副作用。因此，迫切需要开发新的治疗方法以及有效的疫苗来预防HCV感染。了解HCV与宿主细胞之间的相互作用肯定有助于更好地理解疾病进展，并可能揭示新型抗病毒治疗药物开发的潜在新细胞靶点。在此，我们回顾并讨论HCV与宿主细胞固有免疫之间的相互作用。我们重点关注对HCV感染做出反应并加以对抗的不同细胞途径，并强调病毒为逃避这种细胞内反应而制定的逃逸策略。
