Department of Dermatology, Gaziosmanpasa University School of Medicine, Tokat, Turkey.
Photodermatol Photoimmunol Photomed. 2010 Oct;26(5):257-60. doi: 10.1111/j.1600-0781.2010.00526.x.
Scleredema is an uncommon condition characterized by induration of skin. The pathogenesis is not known, although the increased expression of collagen-producing fibroblasts in the skin has been demonstrated. Scleredema has been difficult to treat with scattered reports of success with bath psoralen plus ultraviolet A (PUVA), cream PUVA, UVA1 and others. The use of low-dose broad-band UVA phototherapy was found to be effective in the treatment of morphea. Colchicine has been shown to interfere with collagen synthesis and is used successfully in scleroderma. We report the first case of scleredema that improved markedly with low-dose broad-band UVA plus colchicine treatment.
硬肿症是一种罕见的疾病，其特征为皮肤硬化。其发病机制尚不清楚，尽管已经证明皮肤中产生胶原的成纤维细胞表达增加。硬肿症很难治疗，仅有少数报道称沐浴补骨脂素加紫外线 A（PUVA）、乳膏 PUVA、UVA1 等治疗有效。低剂量广谱 UVA 光疗被发现对硬皮病的治疗有效。秋水仙碱已被证明能干扰胶原合成，并成功用于硬皮病的治疗。我们报告首例硬肿症患者，经低剂量广谱 UVA 联合秋水仙碱治疗后显著改善。
