Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Japan.
Bipolar Disord. 2010 Dec;12(8):804-12. doi: 10.1111/j.1399-5618.2010.00876.x.
Psychiatrists have long debated whether bipolar disorder (BP) and schizophrenia (SZ) are the clinical outcomes of discrete or shared causative processes. SZ shows significantly delayed peak latencies of the evoked neural oscillation (eNO) power and reduced eNO power to speech sounds in the left hemisphere in comparison to normal controls (NC), suggesting deficits in the fast mechanism for identifying speech sounds for SZ. The current study tested the hypothesis that the eNO to speech sounds could be differentiated between BP and SZ patients.
The magnetoencephalographic data of 11 BP, 12 SZ, and 15 NC subjects were evaluated, and we analyzed the eNO power and phase-locking in 20-45 Hz to speech sounds and pure tones in the left hemisphere.
The major findings were that: (i) BP subjects exhibited larger eNO power to speech sounds compared to NC and SZ; (ii) SZ subjects showed delayed eNO and phase-locking to speech sounds specifically in the left hemisphere; and (iii) no significant differences were observed in the response to pure tones among the three groups.
The present study showed that different patterns in eNO to speech sounds are present in BP, SZ, and NC subjects. The eNO to speech sounds in the left hemisphere is a potential index to distinguish BP and SZ.
精神科医生长期以来一直在争论双相情感障碍（BP）和精神分裂症（SZ）是否是不同或共同病因过程的临床结果。与正常对照组（NC）相比，SZ 显示出诱发神经振荡（eNO）功率的明显延迟峰值潜伏期和左侧半球对语音的 eNO 功率降低，这表明 SZ 在识别语音的快速机制上存在缺陷。本研究检验了以下假设，即对语音的 eNO 可以在 BP 和 SZ 患者之间进行区分。
评估了 11 名 BP、12 名 SZ 和 15 名 NC 受试者的脑磁图数据，我们分析了左侧半球对语音和纯音的 20-45Hz 的 eNO 功率和锁相。
主要发现包括：（i）与 NC 和 SZ 相比，BP 受试者对语音的 eNO 功率更大；（ii）SZ 受试者在左侧半球对语音的 eNO 和锁相特别延迟；（iii）三组受试者对纯音的反应无明显差异。
本研究表明，BP、SZ 和 NC 受试者对语音的 eNO 存在不同模式。左侧半球对语音的 eNO 可能是区分 BP 和 SZ 的潜在指标。
