School of Health Care Administration, Gynecology Research Center, Taipei Medical University, Taipei, Taiwan.
Bipolar Disord. 2010 Dec;12(8):859-65. doi: 10.1111/j.1399-5618.2010.00878.x.
We examined a nationwide population-based dataset of patients with bipolar disorder (BD) hospitalized in Taiwan, with our analyses focusing on one-year medical costs and relapse rates.
The data for this study, covering the years 2006 and 2007, were obtained from the Taiwan National Health Insurance (NHI) claims database. The study sample comprised BD patients who were discharged from hospitals between January 1 and December 31, 2006. Annual medical costs and relapse rates were described; the Kaplan-Meier method and the generalized linear models were carried out to examine the risk factors associated with cases of relapse.
The annual medical costs associated with relapses among the study sample were found to be approximately 7.6 times the average per-capita NHI expenditure in Taiwan in 2006 (US$4,354 versus US$574), with a one-year relapse rate of 55%. Those patients between 20 and 60 years old with a medication possession ratio of <80 and with depressive episodes during the recruitment period were identified as being at risk of relapse.
Bipolar disorder, which is a very costly disease, is associated with both poor medication adherence rates and frequent recurrences. Targeting drug adherence issues during maintenance treatment may well provide a valuable opportunity to reduce the risk of such recurrences.
我们分析了在台湾因双相情感障碍（BD）住院的全国性患者人群的基础数据集，重点关注一年内的医疗费用和复发率。
本研究的数据来自于 2006 年和 2007 年的台湾全民健康保险（NHI）理赔数据库。研究样本包括 2006 年 1 月 1 日至 12 月 31 日期间从医院出院的 BD 患者。描述了年度医疗费用和复发率；采用 Kaplan-Meier 法和广义线性模型，分析与复发相关的风险因素。
研究样本中与复发相关的年度医疗费用约为 2006 年台湾人均 NHI 支出（4354 美元）的 7.6 倍（574 美元），一年复发率为 55%。年龄在 20 至 60 岁之间、药物维持率<80%、招募期间有抑郁发作的患者被认为有复发的风险。
双相情感障碍是一种非常昂贵的疾病，与药物依从性差和频繁复发有关。在维持治疗期间针对药物依从性问题进行干预可能是降低复发风险的一个有价值的机会。
