Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
Korean J Intern Med. 2010 Dec;25(4):447-9. doi: 10.3904/kjim.2010.25.4.447. Epub 2010 Nov 27.
A 63-year-old female diagnosed with relapsed multiple myeloma visited our hospital complaining of a persistent cough. Since July 2006, she had been taking 100 mg thalidomide daily and gradually developed shortness of breath and a persistent dry cough. A chest X-ray and computed tomography showed ground glass opacities in both lungs. An open lung biopsy of the right middle lobe under general anesthesia revealed chronic peribronchial inflammation, mild interstitial fibrosis, and intra-alveolar macrophage infiltration, with some hemosiderin features, compatible with non-specific interstitial pneumonia (NSIP). After discontinuing the thalidomide, the patient's symptoms did not deteriorate, although the radiographs did not improve. The patient is alive and well with regular outpatient follow-up without progression of the NSIP.
一位 63 岁女性，被诊断为复发性多发性骨髓瘤，因持续咳嗽来我院就诊。自 2006 年 7 月以来，她一直每天服用 100 毫克沙利度胺，随后逐渐出现呼吸急促和持续干咳。胸部 X 射线和计算机断层扫描显示双肺磨玻璃影。在全身麻醉下对右中叶进行开胸肺活检显示慢性细支气管周围炎症、轻度间质纤维化和肺泡内巨噬细胞浸润，具有一些含铁血黄素特征，符合非特异性间质性肺炎（NSIP）。停用沙利度胺后，尽管 X 射线没有改善，但患者的症状没有恶化。该患者定期门诊随访，情况良好，NSIP 无进展。
