肾源性系统性纤维化的病理生理学：实验数据综述
Pathophysiology of nephrogenic systemic fibrosis: A review of experimental data.
作者信息
Morcos Sameh K, Haylor John
机构信息
Sameh K Morcos, Department of Diagnostic Imaging, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, United Kingdom.
出版信息
World J Radiol. 2010 Nov 28;2(11):427-33. doi: 10.4329/wjr.v2.i11.427.
Abstract
Since the association between nephrogenic systemic fibrosis (NSF) and gadolinium contrast agents (Gd-CAs) was suggested in 2006, several experimental studies have been published to elucidate the role of these agents in the pathogenesis of NSF. Low stability Gd-CAs have a stimulant effect on human skin and fibroblasts in culture and modulate the production of collagen by these cells. Low stability agents have also induced NSF-like skin changes in a rat model with normal renal function after multiple repeat administrations. The role of the 5/6 subtotal nephrectomy rat model in investigating NSF remains under evaluation.
摘要
自2006年有人提出肾源性系统性纤维化（NSF）与钆对比剂（Gd - CAs）之间存在关联以来，已发表了多项实验研究以阐明这些药物在NSF发病机制中的作用。低稳定性Gd - CAs对培养中的人皮肤和成纤维细胞有刺激作用，并调节这些细胞的胶原蛋白生成。多次重复给药后，低稳定性药物在肾功能正常的大鼠模型中也诱发了类似NSF的皮肤变化。5/6肾大部切除大鼠模型在研究NSF中的作用仍在评估中。
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