Hadar Ravit, Menzel Randolf
Neurobiology, Institut für Biologie, Freie Universität Berlin Berlin, Germany.
Front Behav Neurosci. 2010 Dec 13;4:186. doi: 10.3389/fnbeh.2010.00186. eCollection 2010.
In reversal learning animals are first trained with a differential learning protocol, where they learn to respond to a reinforced odor (CS+) and not to respond to a non-reinforced odor (CS-). Once they respond correctly to this rule, the contingencies of the conditioned stimuli are reversed, and animals learn to adjust their response to the new rule. This study investigated the effect of a protein synthesis inhibitor (emetine) on the memory formed after reversal learning in the honeybee Apis mellifera. Two groups of bees were studied: summer bees and winter bees, each yielded different results. Blocking protein synthesis in summer bees inhibits consolidation of the excitatory learning following reversal learning whereas it blocked the consolidation of the inhibitory learning in winter bees. These findings suggest that excitatory and inhibitory learning may involve different molecular processes in bees, which are seasonally dependent.
在反转学习中，动物首先接受差异学习训练，即学习对强化气味（条件刺激+，CS+）做出反应，而不对非强化气味（条件刺激-，CS-）做出反应。一旦它们正确遵循此规则，条件刺激的偶然性就会反转，动物需要学习根据新规则调整反应。本研究调查了蛋白质合成抑制剂（吐根碱）对蜜蜂（西方蜜蜂）反转学习后形成的记忆的影响。研究了两组蜜蜂：夏季蜜蜂和冬季蜜蜂，每组得到了不同的结果。阻断夏季蜜蜂的蛋白质合成会抑制反转学习后兴奋性学习的巩固，而阻断冬季蜜蜂的蛋白质合成则会抑制抑制性学习的巩固。这些发现表明，兴奋性和抑制性学习在蜜蜂中可能涉及不同的分子过程，且这些过程具有季节性依赖性。
