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消退记忆的巩固取决于训练期间先前经历的无条件刺激强度。

Consolidation of an extinction memory depends on the unconditioned stimulus magnitude previously experienced during training.

作者信息

Stollhoff Nicola, Eisenhardt Dorothea

机构信息

Freie Universität Berlin, Department of Biology/Chemistry/Pharmacy, Institute for Biology, Neurobiology, 14195 Berlin, Germany.

出版信息

J Neurosci. 2009 Jul 29;29(30):9644-50. doi: 10.1523/JNEUROSCI.0495-09.2009.

DOI:10.1523/JNEUROSCI.0495-09.2009
PMID:19641127
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6666547/
Abstract

Here, we examine the role of the magnitude of the unconditioned stimulus (US) during classical conditioning in consolidation processes after memory retrieval. We varied the US durations during training and we test the impact of these variations on consolidation after memory retrieval with one or two conditioned stimulus-only trials. We found that the consolidation of an extinction memory depends on US duration during training and ruled out the possibility that this effect is attributable to differences in satiation after conditioning. We conclude that consolidation of an extinction memory is triggered only when the duration of the US reaches a critical threshold. This demonstrates that memory consolidation cannot be regarded as an isolated process depending solely on training conditions. Instead, it depends on the animal's previous experience as well.

摘要

在此，我们研究了经典条件反射过程中无条件刺激（US）的强度在记忆提取后巩固过程中的作用。我们在训练期间改变了US的持续时间，并通过一两次仅呈现条件刺激的试验来测试这些变化对记忆提取后巩固的影响。我们发现消退记忆的巩固取决于训练期间的US持续时间，并排除了这种效应归因于条件反射后饱足感差异的可能性。我们得出结论，只有当US的持续时间达到临界阈值时，消退记忆的巩固才会被触发。这表明记忆巩固不能被视为仅取决于训练条件的孤立过程。相反，它还取决于动物先前的经验。

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本文引用的文献

1
An identified neuron mediates the unconditioned stimulus in associative olfactory learning in honeybees.一个已确定的神经元在蜜蜂的联想嗅觉学习中介导无条件刺激。
Nature. 1993 Nov 4;366:59-63. doi: 10.1038/366059a0.
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A switch from cycloheximide-resistant consolidated memory to cycloheximide-sensitive reconsolidation and extinction in Drosophila.在果蝇中，记忆从对放线菌酮有抗性的巩固记忆转变为对放线菌酮敏感的再巩固和消退。
J Neurosci. 2009 Feb 18;29(7):2225-30. doi: 10.1523/JNEUROSCI.3789-08.2009.
3
Does an insect's unconditioned response to sucrose reveal expectations of reward?昆虫对蔗糖的无条件反应是否揭示了对奖励的预期？
PLoS One. 2008 Jul 30;3(7):e2810. doi: 10.1371/journal.pone.0002810.
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One retrieval trial induces reconsolidation in an appetitive learning paradigm in honeybees (Apis mellifera).一次检索试验在蜜蜂（西方蜜蜂）的一种味觉学习范式中引发再巩固。
Neurobiol Learn Mem. 2008 May;89(4):419-25. doi: 10.1016/j.nlm.2007.10.003. Epub 2007 Dec 3.
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Neural mechanisms of extinction learning and retrieval.消退学习与提取的神经机制。
Neuropsychopharmacology. 2008 Jan;33(1):56-72. doi: 10.1038/sj.npp.1301555. Epub 2007 Sep 19.
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Learning reward expectations in honeybees.蜜蜂学习奖励预期。
Learn Mem. 2007 Jul 12;14(7):491-6. doi: 10.1101/lm.618907. Print 2007 Jul.
7
Effect of unconditioned stimulus magnitude on the emergence of conditioned responding.无条件刺激强度对条件反应出现的影响。
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