Xu Z, Xu W, Chen Z
Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
Zhen Ci Yan Jiu. 1990;15(1):77-81, 29.
We have previously demonstrated that during acute arthritis in the rats induced by local intraplanter adjuvant, there are dramatic alterations in the behavioral responses to noxious stimulation. The purpose of this study was to observe the changes in responses of parafascicular nuclei (Pf) neurons during acute arthritis and effect of acupuncture (EA) in the rats. It was shown that: (1). for the whole populations of somatosensory neurons there was no statistical significant between arthritic rat and normal rat (P greater than 0.05). However, nociceptive neurons activated exclusively by noxious stimulation were less in the arthritic rat (21/60) than in the normal rat (35/46) (P less than 0.01); nociceptive-non-nociceptive neurons activated by both noxious and non-noxious stimulation were more in the arthritic rat (30/60) than in the normal rat (9/46) (P less than 0.01), and there was no statistical significant different for population of non-nociceptive neurons between two groups. (2). Nociceptive responses of Pf neurons (n = 16) could be markedly inhibited by EA at Xuanzhong (G39) and Kunlun (B60) in acute arthritic rat. In particular, the inhibitory effect was of great significance (P less than 0.01) during 0-10 and 20-35 minutes following cessation of EA. These results suggest that rats were hyperalgesic during adjuvant-induced acute arthritis and EA produces a fine analgesic effect in acute arthritic rats. The results also support the view that adjuvant-induced acute arthritic rat can be considered as a model for research of pain and analgesia.
我们之前已经证明，在足底局部注射佐剂诱导的大鼠急性关节炎期间，对伤害性刺激的行为反应会发生显著改变。本研究的目的是观察大鼠急性关节炎期间束旁核（Pf）神经元反应的变化以及针刺（电针）的影响。结果表明：（1）. 对于整个体感神经元群体，关节炎大鼠和正常大鼠之间没有统计学显著差异（P大于0.05）。然而，仅由伤害性刺激激活的伤害性神经元在关节炎大鼠中（21/60）比正常大鼠中（35/46）少（P小于0.01）；由伤害性和非伤害性刺激均激活的伤害性 - 非伤害性神经元在关节炎大鼠中（30/60）比正常大鼠中（9/46）多（P小于0.01），并且两组之间非伤害性神经元群体没有统计学显著差异。（2）. 在急性关节炎大鼠中，电针悬钟（G39）和昆仑（B60）可显著抑制Pf神经元（n = 16）的伤害性反应。特别是，在电针停止后的0 - 10分钟和20 - 35分钟期间，抑制作用具有高度显著性（P小于0.01）。这些结果表明，在佐剂诱导的急性关节炎期间大鼠存在痛觉过敏，并且电针在急性关节炎大鼠中产生良好的镇痛效果。这些结果也支持这样一种观点，即佐剂诱导的急性关节炎大鼠可被视为疼痛和镇痛研究的模型。
