造血干细胞微环境的建立与调控：成骨细胞和血管区室的作用。
Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments.
作者信息
Coskun Suleyman, Hirschi Karen K
机构信息
Center for Cell and Gene Therapy, Baylor College of Medicine; Houston, Texas, 77030, USA.
出版信息
Birth Defects Res C Embryo Today. 2010 Dec;90(4):229-42. doi: 10.1002/bdrc.20194.
Abstract
Hematopoietic stem cells (HSC) are multi-potent cells that function to generate a lifelong supply of all blood cell types. During mammalian embryogenesis, sites of hematopoiesis change over the course of gestation: from extraembryonic yolk sac and placenta, to embryonic aorta-gonad-mesonephros region, fetal liver, and finally fetal bond marrow where HSC reside postnatally. These tissues provide microenviroments for de novo HSC formation, as well as HSC maturation and expansion. Within adult bone marrow, HSC self-renewal and differentiation are thought to be regulated by two major cellular components within their so-called niche: osteoblasts and vascular endothelial cells. This review focuses on HSC generation within, and migration to, different tissues during development, and also provides a summary of major regulatory factors provided by osteoblasts and vascular endothelial cells within the adult bone marrow niche.
摘要
造血干细胞（HSC）是多能细胞，其功能是终身产生所有类型的血细胞。在哺乳动物胚胎发育过程中，造血部位在妊娠期会发生变化：从胚胎外卵黄囊和胎盘，到胚胎主动脉-性腺-中肾区域、胎儿肝脏，最后是胎儿骨髓，出生后造血干细胞就存在于胎儿骨髓中。这些组织为造血干细胞的从头形成以及成熟和扩增提供微环境。在成年骨髓中，造血干细胞的自我更新和分化被认为受其所谓龛内的两种主要细胞成分调节：成骨细胞和血管内皮细胞。本综述重点关注发育过程中造血干细胞在不同组织内的产生和迁移，并总结成年骨髓龛内成骨细胞和血管内皮细胞提供的主要调节因子。
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Blood. 2010 Oct 28;116(17):3185-96. doi: 10.1182/blood-2009-12-260703. Epub 2010 Jul 14.
2
Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.体内骨髓造血和基质细胞相对于血流的定位：连续重建的造血干细胞位于独特的非灌注龛位。
Blood. 2010 Jul 22;116(3):375-85. doi: 10.1182/blood-2009-07-233437. Epub 2010 Apr 14.
3
Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells.胎肝中的肝祖细胞是造血干细胞的支持性基质细胞。
Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7799-804. doi: 10.1073/pnas.1003586107. Epub 2010 Apr 12.
4
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Nat Med. 2010 Apr;16(4):475-82. doi: 10.1038/nm.2119. Epub 2010 Mar 21.
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Cell Stem Cell. 2010 Mar 5;6(3):251-64. doi: 10.1016/j.stem.2010.02.001.
6
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Nature. 2010 Mar 4;464(7285):108-11. doi: 10.1038/nature08738. Epub 2010 Feb 14.
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