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Circulating levels and hepatic expression of molecular mediators of atherosclerosis in nonalcoholic fatty liver disease.非酒精性脂肪性肝病中动脉粥样硬化分子介质的循环水平和肝表达。
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Second-hand smoke stimulates lipid accumulation in the liver by modulating AMPK and SREBP-1.二手烟通过调节 AMPK 和 SREBP-1 刺激肝脏脂质积累。
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Relationships of PAI-1 levels to central obesity and liver steatosis in a sample of adult male population in southern Italy.意大利南部成年男性样本中纤溶酶原激活物抑制剂-1（PAI-1）水平与中心性肥胖及肝脂肪变性的关系。
Intern Emerg Med. 2009 Aug;4(4):315-23. doi: 10.1007/s11739-009-0240-9. Epub 2009 Apr 7.
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Could inflammatory markers help diagnose nonalcoholic steatohepatitis?炎症标志物能否有助于诊断非酒精性脂肪性肝炎？
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Diagnostic value of a computerized hepatorenal index for sonographic quantification of liver steatosis.计算机化肝肾指数对肝脏脂肪变性超声定量诊断的价值
AJR Am J Roentgenol. 2009 Apr;192(4):909-14. doi: 10.2214/AJR.07.4016.
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Venous thromboembolism in patients with cancer and its relationship to the coagulation cascade and vascular endothelial growth factor.癌症患者的静脉血栓栓塞及其与凝血级联反应和血管内皮生长因子的关系。
Support Cancer Ther. 2005 Oct 1;3(1):28-34. doi: 10.3816/SCT.2005.n.022.
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Metabolic syndrome, haemostasis and thrombosis.代谢综合征、止血与血栓形成。
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8
Impact of sex and traditional cardiovascular risk factors on the risk of recurrent venous thromboembolism: results from the German MAISTHRO Registry.性别和传统心血管危险因素对复发性静脉血栓栓塞风险的影响：来自德国MAISTHRO注册研究的结果
Blood Coagul Fibrinolysis. 2008 Mar;19(2):159-65. doi: 10.1097/MBC.0b013e3282f54558.
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Venous thromboembolism in association with features of the metabolic syndrome.与代谢综合征特征相关的静脉血栓栓塞症
QJM. 2007 Nov;100(11):679-84. doi: 10.1093/qjmed/hcm083. Epub 2007 Sep 10.
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Venous thromboembolism--a manifestation of the metabolic syndrome.静脉血栓栓塞症——代谢综合征的一种表现。
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特发性静脉血栓栓塞患者中非酒精性脂肪肝的高患病率。

High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism.

机构信息

Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Via S. Pansini, 5, 80131 Naples, Italy.

出版信息

World J Gastroenterol. 2010 Dec 28;16(48):6119-22. doi: 10.3748/wjg.v16.i48.6119.

DOI:10.3748/wjg.v16.i48.6119
PMID:21182227
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3012581/
Abstract

AIM

to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with idiopathic venous thromboembolism (VTE).

METHODS

in a case-control study, after excluding subjects with well-consolidated risk factors for VTE, idiopathic VTE was documented in 138 consecutive patients who were referred to our department. Two hundred and seventy-six healthy sex/age/body-mass-index-matched subjects, without any clinical/instrumental evidence of VTE, served as controls. All underwent a clinical/laboratory/ultrasound assessment for the presence of metabolic syndrome and NAFLD.

RESULTS

NAFLD was detected in 112/138 cases (81%) and in 84/276 controls (30%) [risk ratio: 2.7, 95% confidence interval (CI): 2.2-3.2, P < 0.0001]. Metabolic syndrome and smoking habit were more prevalent in patients with idiopathic VTE. The high prevalence of NAFLD in VTE was also confirmed after adjustment for inherited thrombophilia. NAFLD was clearly predicted by VTE (odds ratio: 1.8, 95% CI: 1.2-2.7, P < 0.0001).

CONCLUSION

NAFLD was independently associated with idiopathic VTE.

摘要

目的

评估特发性静脉血栓栓塞症（VTE）患者中非酒精性脂肪性肝病（NAFLD）的患病率。

方法

在一项病例对照研究中，排除 VTE 明确危险因素后，对我院收治的 138 例特发性 VTE 患者进行了病例记录。276 名性别/年龄/体重指数匹配、无任何临床/仪器 VTE 证据的健康受试者作为对照组。所有受试者均接受了代谢综合征和 NAFLD 的临床/实验室/超声评估。

结果

138 例患者中有 112 例（81%）和 276 例对照组中有 84 例（30%）检测到 NAFLD[风险比：2.7，95%置信区间（CI）：2.2-3.2，P<0.0001]。特发性 VTE 患者中代谢综合征和吸烟习惯更为常见。在调整遗传性血栓形成倾向后，VTE 患者中 NAFLD 的高患病率仍然成立。NAFLD 可明确预测 VTE（比值比：1.8，95% CI：1.2-2.7，P<0.0001）。

结论

NAFLD 与特发性 VTE 独立相关。