特发性静脉血栓栓塞患者中非酒精性脂肪肝的高患病率。
High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism.
机构信息
Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
出版信息
World J Gastroenterol. 2010 Dec 28;16(48):6119-22. doi: 10.3748/wjg.v16.i48.6119.
AIM
to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with idiopathic venous thromboembolism (VTE).
METHODS
in a case-control study, after excluding subjects with well-consolidated risk factors for VTE, idiopathic VTE was documented in 138 consecutive patients who were referred to our department. Two hundred and seventy-six healthy sex/age/body-mass-index-matched subjects, without any clinical/instrumental evidence of VTE, served as controls. All underwent a clinical/laboratory/ultrasound assessment for the presence of metabolic syndrome and NAFLD.
RESULTS
NAFLD was detected in 112/138 cases (81%) and in 84/276 controls (30%) [risk ratio: 2.7, 95% confidence interval (CI): 2.2-3.2, P < 0.0001]. Metabolic syndrome and smoking habit were more prevalent in patients with idiopathic VTE. The high prevalence of NAFLD in VTE was also confirmed after adjustment for inherited thrombophilia. NAFLD was clearly predicted by VTE (odds ratio: 1.8, 95% CI: 1.2-2.7, P < 0.0001).
CONCLUSION
NAFLD was independently associated with idiopathic VTE.
目的
评估特发性静脉血栓栓塞症（VTE）患者中非酒精性脂肪性肝病（NAFLD）的患病率。
方法
在一项病例对照研究中，排除 VTE 明确危险因素后，对我院收治的 138 例特发性 VTE 患者进行了病例记录。276 名性别/年龄/体重指数匹配、无任何临床/仪器 VTE 证据的健康受试者作为对照组。所有受试者均接受了代谢综合征和 NAFLD 的临床/实验室/超声评估。
结果
138 例患者中有 112 例（81%）和 276 例对照组中有 84 例（30%）检测到 NAFLD[风险比：2.7，95%置信区间（CI）：2.2-3.2，P<0.0001]。特发性 VTE 患者中代谢综合征和吸烟习惯更为常见。在调整遗传性血栓形成倾向后，VTE 患者中 NAFLD 的高患病率仍然成立。NAFLD 可明确预测 VTE（比值比：1.8，95% CI：1.2-2.7，P<0.0001）。
结论
NAFLD 与特发性 VTE 独立相关。
Zotero 插件