抗心磷脂抗体及免疫异常在萎缩性硬化性苔藓样血管炎中的意义

The significance of anticardiolipin antibody and immunologic abnormality in livedoid vasculitis.

作者信息

Feng Su-ying, Jin Pei-ying, Shao Chang-geng

机构信息

Institute of Dermatology, Chinese Academy of Medical Sciences, Peking Union Medical College, Nanjing, China.

出版信息

Int J Dermatol. 2011 Jan;50(1):21-3. doi: 10.1111/j.1365-4632.2010.04569.x.

DOI:10.1111/j.1365-4632.2010.04569.x

PMID:21182497

Abstract

OBJECTIVE

To evaluate the significance of anticardiolipin and immunologic abnormality in the livedoid vasculitis (LV).

METHODS

30 patients with biopsy-proven LV and 30 normal controls involved in the study. Indirect immunofluorescence, immunoblot, and ELISA were used for detecting antinuclear antibody (ANA), circulating immune complex, immune globulin, anticardiophospholipin antibody (ACA), and anti-β(2) GP1.

RESULTS

ANA was positive in four patients with LV, and among them, two patients were diagnosed as Systemic Lupus Erythematosus (SLE) later. Addition to the two SLE patients, the level of ENA and immunoglobulin were normal in the rest of patients. Anticardiolipin antibodies were present in 13 (43.33%), and β(2) GP1 was present in nine (30%) of 30 patients. There were significant differences between LV and controls.

CONCLUSIONS

ACA is one of important pathogenesis of LV. Numerous heterogeneous coagulation abnormalities and thrombogenesis may involve the LV.

摘要

目的

评估抗心磷脂及免疫异常在青斑样血管炎（LV）中的意义。

方法

30例经活检证实为LV的患者及30名正常对照者参与本研究。采用间接免疫荧光法、免疫印迹法及酶联免疫吸附测定法检测抗核抗体（ANA）、循环免疫复合物、免疫球蛋白、抗心磷脂抗体（ACA）及抗β2糖蛋白1。

结果

4例LV患者ANA呈阳性，其中2例后来被诊断为系统性红斑狼疮（SLE）。除这2例SLE患者外，其余患者的可提取核抗原（ENA）及免疫球蛋白水平均正常。30例患者中，13例（43.33%）存在抗心磷脂抗体，9例（30%）存在β2糖蛋白1。LV患者与对照组之间存在显著差异。结论：ACA是LV的重要发病机制之一。多种异质性凝血异常及血栓形成可能与LV有关。