“多发性硬化症病毒”的探寻——脑提取物对鸡、小鼠和大鼠髓鞘发育无影响

A search for the "multiple sclerosis virus"--lack of effect of brain extracts on myelin development in chickens, mice and rats.

作者信息

Sims N R, Bernard C C, Horvath L, Mackay I R, Carnegie P R

出版信息

Adv Exp Med Biol. 1978;100:411-22. doi: 10.1007/978-1-4684-2514-7_29.

Abstract

Attempts were made to transmit possible infectious agents from tissue of MS patients into three animal species, under conditions designed to enhance the development of such an agent. Myelination was monitored by measuring CNPase activity and myelin basic protein. Although no significant effects were observed, the usefulness of a new assay for CNPase was demonstrated. Nude mice were found to have a lower level of CNPase than their heterozygous littermates.

摘要

研究人员试图在旨在促进此类病原体生长的条件下，将多发性硬化症（MS）患者组织中可能存在的传染性病原体传播给三种动物。通过测量2',3'-环核苷酸3'-磷酸二酯酶（CNPase）活性和髓鞘碱性蛋白来监测髓鞘形成。虽然未观察到显著影响，但证明了一种新的CNPase检测方法的有效性。发现裸鼠的CNPase水平低于其杂合子同窝小鼠。