Louvain Centre for Toxicology and Applied Pharmacology (LTAP), Université catholique de Louvain, Avenue E. Mounier 53.02, 1200 Brussels, Belgium.
Toxicol Lett. 2011 Feb 25;201(1):42-6. doi: 10.1016/j.toxlet.2010.12.003. Epub 2010 Dec 21.
Hypothyroidism has been observed in the fifties and sixties as an undesirable side-effect of cobalt therapy used for its erythropoietic properties in the treatment of anemia.
This study aims at evaluating the possible impact of both cumulative (long-term) and recent occupational exposure to cobalt on thyroid function and red blood cells.
A cross-sectional survey was conducted from February 2008 to August 2009 in a population of 249 male workers from a cobalt production department in the North of Belgium. The possible effect of cobalt exposure on thyroid and red blood cells was investigated through multiple regression analyses.
Blood cobalt ranged from undetectable to 3.20 μg/100ml (median 0.10); urinary cobalt from 0.30 to 204.30 μg/g(creat) (median 3.90) and long-term exposure to cobalt ranged from 0.15 to 6990.46 μg/g(creat) · years (median 106.09). No effect of cobalt exposure on thyroid or red blood cell parameters was observed at these levels of exposure.
The results support the absence of effects on the thyroid and red blood cells when occupational exposure to cobalt is kept below the recommended biological limit of occupational exposure (15 μg Co/g(creat) in urine).
在五六十年代，由于钴的促红细胞生成作用，被用于治疗贫血，但其治疗带来了甲状腺功能减退等不良副作用。
本研究旨在评估长期和近期职业性暴露于钴对甲状腺功能和红细胞的潜在影响。
2008 年 2 月至 2009 年 8 月，在比利时北部一家钴生产部门对 249 名男性工人进行了横断面调查。通过多元回归分析，研究了钴暴露对甲状腺和红细胞的可能影响。
血钴浓度范围为检测不到至 3.20μg/100ml（中位数 0.10）；尿钴浓度范围为 0.30 至 204.30μg/g(creat)（中位数 3.90），长期钴暴露范围为 0.15 至 6990.46μg/g(creat)·年（中位数 106.09）。在这些暴露水平下，钴暴露对甲状腺或红细胞参数没有影响。
当职业性暴露于钴保持在推荐的职业性暴露生物限量（尿钴 15μg Co/g(creat)）以下时，结果支持钴暴露对甲状腺和红细胞没有影响。
