Ströhle Alexander, Wolters Maike, Hahn Andreas
Institute of Food Science and Human Nutrition, Leibniz University of Hannover, Hannover, Germany.
Inflamm Allergy Drug Targets. 2011 Feb;10(1):54-63. doi: 10.2174/187152811794352105.
As elements of the antioxidant system, cofactors of enzymes, components of transcription factors, and epigenetic modulators, micronutrients, such as vitamins and trace elements, influence various metabolic processes that are directly associated with immune functions. Specifically, the vitamins C and D have been shown to have significance immune function. Therefore, the objective of this review is to elucidate interactions between micronutrients and the immune system. In the initial section of this review, we present a general overview of interactions between the immune system and micronutrients, with a focus on the immunobiologically relevant functions of vitamin C. Immune competent cells accumulate vitamin C against a concentration gradient, with a close relationship between vitamin C supply and immune cell activity, especially phagocytosis activity and T-cell function. Accordingly, one of the consequences of vitamin C deficiency is impaired resistance to various pathogens, while an enhanced supply increases antibody activity and infection resistance.
作为抗氧化系统的组成部分、酶的辅助因子、转录因子的成分以及表观遗传调节剂，维生素和微量元素等微量营养素会影响与免疫功能直接相关的各种代谢过程。具体而言，维生素C和D已被证明具有重要的免疫功能。因此，本综述的目的是阐明微量营养素与免疫系统之间的相互作用。在本综述的开篇部分，我们将对免疫系统与微量营养素之间的相互作用进行总体概述，重点关注维生素C的免疫生物学相关功能。免疫活性细胞会逆浓度梯度积累维生素C，维生素C的供应与免疫细胞活性，尤其是吞噬活性和T细胞功能之间存在密切关系。因此，维生素C缺乏的后果之一是对各种病原体的抵抗力受损，而增加供应则会增强抗体活性和抗感染能力。
