心外膜脂肪：亚临床动脉粥样硬化和心血管风险分层的附加测量指标？
Epicardial fat: an additional measurement for subclinical atherosclerosis and cardiovascular risk stratification?
机构信息
Mayo Clinic, Scottsdale, AZ, USA.
出版信息
J Am Soc Echocardiogr. 2011 Mar;24(3):339-45. doi: 10.1016/j.echo.2010.11.008. Epub 2010 Dec 24.
BACKGROUND
The value of epicardial adipose tissue (EAT) thickness as determined by echocardiography in cardiovascular risk assessment is not well understood. The aim of this study was to determine the associations between EAT thickness and Framingham risk score, carotid intima media thickness, carotid artery plaque, and computed tomographic coronary calcium score in a primary prevention population.
METHODS
Patients presenting for cardiovascular preventive care (n = 356) who underwent echocardiography as well as carotid artery ultrasound and/or coronary calcium scoring were included.
RESULTS
EAT thickness was weakly correlated with Framingham risk score. The prevalence of carotid plaque was significantly greater in those with EAT thickness ≥ 5.0 mm who either had low Framingham risk scores or had body mass indexes ≥ 25 kg/m(2), compared with those with EAT thickness <5.0 mm. No significant association between EAT thickness and carotid intima-media thickness or coronary calcium score existed.
CONCLUSION
EAT thickness ≥ 5.0 mm may identify an individual with a higher likelihood of having detectable carotid atherosclerosis.
背景
超声心动图测量的心外膜脂肪组织（EAT）厚度在心血管风险评估中的价值尚未得到充分理解。本研究旨在确定在一级预防人群中，EAT 厚度与弗雷明汉风险评分、颈动脉内膜中层厚度、颈动脉斑块和计算机断层扫描冠状动脉钙评分之间的关系。
方法
纳入了 356 例因心血管预防保健而就诊并接受超声心动图以及颈动脉超声和/或冠状动脉钙评分检查的患者。
结果
EAT 厚度与弗雷明汉风险评分呈弱相关。与 EAT 厚度<5.0mm 的患者相比，EAT 厚度≥5.0mm 且弗雷明汉风险评分低或体重指数≥25kg/m2 的患者颈动脉斑块的发生率显著更高。EAT 厚度与颈动脉内膜中层厚度或冠状动脉钙评分之间无显著相关性。
结论
EAT 厚度≥5.0mm 可能提示存在可检测的颈动脉粥样硬化的个体的可能性更高。
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